The usage of dendrimers or cascade molecules in the biomedical area has recently attracted much attention worldwide. Furthermore, dendrimers are interesting in clinical and pre-clinical applications due to their unique characteristics. Cancer is one of the most widespread challenges and important diseases, which has the highest mortality rate. In this review, the recent advances and developments (from 2009 up to 2019) in the field of electrochemical and electroluminescence immunosensors for detection of the cancer markers are presented. Moreover, this review covers the basic fabrication principles and types of electrochemical and electrochemiluminescence dendrimer-based immunosensors. In this review, we have categorized the current dendrimer based-electrochemical/ electroluminescence immunosensors into five groups: dendrimer/ magnetic particles, dendrimer/ferrocene, dendrimer/metal nanoparticles, thiol-containing dendrimer, and dendrimer/quantum dots based-immunosensors.