jak2介导的细胞内信号传导

Title:JAK2-mediated Intracellular Signaling

Volume: 21 Issue: 5

关键词: Jak2、STAT、蛋白激酶、激素，细胞内信号传导，细胞因子受体。

摘要: Janus kinase-2 (JAK2) is a non-receptor tyrosine kinase that serves key roles as the intracellular signaling effector of the cytokine receptor, such as mediating effects of leptin, erythropoietin, interferon, and growth hormone. A lot of molecular underlying mechanisms of JAK2 participation are known, however, additional signaling mechanisms of its activation, regulation, and pleiotropic signaling roles are still being explored. Here, we review the current knowledge of JAK2-mediated cellular signaling at the molecular level. In the beginning, we will focus on the recent advances in JAK2 activation and regulation. A part of our review focuses on the JAK2 involvement in various diseases/conditions. Recent advances highlight the molecular regulatory mechanisms utilized by the JAK2 signaling, thus, enabling to consider alternative therapeutic strategies to treat various diseases/conditions mediated by JAK2 by using it as a therapeutic target.

Cite this article as:

JAK2-mediated Intracellular Signaling, Current Molecular Medicine 2021; 21 (5) . https://dx.doi.org/10.2174/1566524020666201015144702