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Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Review Article

JAK2-mediated Intracellular Signaling

Author(s): Mentor Sopjani*, Rifat Morina, Valdet Uka, Nguyen Thi Xuan and Miribane Dërmaku-Sopjani*

Volume 21 , Issue 5 , 2021

Published on: 15 October, 2020

Page: [417 - 425] Pages: 9

DOI: 10.2174/1566524020666201015144702

Price: $65

Abstract

Janus kinase-2 (JAK2) is a non-receptor tyrosine kinase that serves key roles as the intracellular signaling effector of the cytokine receptor, such as mediating effects of leptin, erythropoietin, interferon, and growth hormone. A lot of molecular underlying mechanisms of JAK2 participation are known, however, additional signaling mechanisms of its activation, regulation, and pleiotropic signaling roles are still being explored. Here, we review the current knowledge of JAK2-mediated cellular signaling at the molecular level. In the beginning, we will focus on the recent advances in JAK2 activation and regulation. A part of our review focuses on the JAK2 involvement in various diseases/conditions. Recent advances highlight the molecular regulatory mechanisms utilized by the JAK2 signaling, thus, enabling to consider alternative therapeutic strategies to treat various diseases/conditions mediated by JAK2 by using it as a therapeutic target.

Keywords: Jak2, STAT, protein kinases, hormones, intracellular signaling, cytokine receptor.


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