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Current Cardiology Reviews


ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Review Article

The Role of Reactive Oxygen Species, Kinases, Hydrogen Sulfide, and Nitric Oxide in the Regulation of Autophagy and Their Impact on Ischemia and Reperfusion Injury in the Heart

Author(s): Andrey Krylatov, Leonid Maslov*, Sergey Y. Tsibulnikov, Nikita Voronkov, Alla Boshchenko, James Downey and Robert Mentzer

Volume 17, Issue 4, 2021

Published on: 14 October, 2020

Article ID: e230421186874 Pages: 9

DOI: 10.2174/1573403X16666201014142446

Price: $65


There is considerable evidence that autophagy in cardiomyocytes is activated by hypoxia/ reoxygenation (H/R) or in hearts by ischemia/reperfusion (I/R). Depending upon the experimental model and duration of ischemia, increases in autophagy in this setting maybe beneficial (cardioprotective) or deleterious (exacerbate I/R injury). Besides the conundrum as to whether or not autophagy is an adaptive process, it is clearly regulated by a number of diverse molecules, including reactive oxygen species (ROS), various kinases, hydrogen sulfide (H2S) and nitric oxide (NO). The purpose of this review was to address briefly the controversy regarding the role of autophagy in this setting and to examine a variety of disparate molecules that are involved in its regulation.

Keywords: Autophagy, heart, ischemia, reperfusion, kinases, H2S, nitric oxide.

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