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The Natural Products Journal


ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Research Article

Effect of Barley Grain on Memory and Brain’s Oxidative Stress Factors in Male Rats

Author(s): Batool Shakiba-Jam, Azam Moghani, Marzieh Kafami*, Mahmoud Hosseini, Masoud Hosseinzadeh and Adel Naeimi

Volume 11, Issue 5, 2021

Published on: 06 October, 2020

Article ID: e061020186686 Pages: 7

DOI: 10.2174/2210315510999201006200857

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Background & Objective: Barley is widely used as a major staple of human food and animal feed. Several antioxidant phenols are found in barely, which have scavenging properties. The present study aimed to assess the protective effects of barley seed against the oxidative damage of brain tissues in a scopolamine-induced memory impairment model.

Materials and Methods: In total, 32 male albino rats (mean weight: 250±10 g) were divided into four groups of saline (control), scopolamine, barley seed (100 mg/kg) with scopolamine, and barley seed alone. The spatial memory function was assessed using the Morris water maze.

Results: Compared to the scopolamine group, barley seed could decrease the escape latency time in the treated rats, while the time spent and distance traveled in the target quadrant on the probe trial increased. Moreover, barley seed could increase the malondialdehyde concentration in the hippocampus and cortical tissues, while the thiol content was observed to decrease.

Conclusion: According to the results, the use of dietary barley seed could improve the memory function in dementia associated with increased oxidative stress.

Keywords: Barley, scopolamine, memory, oxidative stress, malondialdehyde, antioxidant phenols, dementia.

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