Abstract
Background: Quinacrine is an older antimalarial drug that remains in use for a variety of illnesses including treatment-resistant giardiasis.
Case Presentation: We report a patient with no prior psychiatric history who developed mild, prodromal psychiatric symptoms when treated with quinacrine for treatment-resistant giardiasis. Symptoms resolved when the drug was stopped, recurred with greater severity (requiring involuntary psychiatric hospitalization) when restarted and promptly resolved again when the drug was finally stopped.
Conclusion: Although quinacrine remains in use today, providers may be unaware of its potential for serious neuropsychiatric toxicity.
Keywords: Quinacrine, quinolines, psychosis, adverse drug reaction, case report, giardiasis.
Current Drug Safety
Title:A Case of Quinacrine-induced Psychosis: Case Report
Volume: 16 Issue: 3
Author(s): Anangamanjari Pedapudi*, Jonathan Stewart and Ankita Patel
Affiliation:
- Department of Psychiatry and Behavioral Neurosciences, University of South Florida Morsani College of Medicine, Tampa, FL33612,United States
Keywords: Quinacrine, quinolines, psychosis, adverse drug reaction, case report, giardiasis.
Abstract:
Background: Quinacrine is an older antimalarial drug that remains in use for a variety of illnesses including treatment-resistant giardiasis.
Case Presentation: We report a patient with no prior psychiatric history who developed mild, prodromal psychiatric symptoms when treated with quinacrine for treatment-resistant giardiasis. Symptoms resolved when the drug was stopped, recurred with greater severity (requiring involuntary psychiatric hospitalization) when restarted and promptly resolved again when the drug was finally stopped.
Conclusion: Although quinacrine remains in use today, providers may be unaware of its potential for serious neuropsychiatric toxicity.
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Cite this article as:
Pedapudi Anangamanjari *, Stewart Jonathan and Patel Ankita , A Case of Quinacrine-induced Psychosis: Case Report, Current Drug Safety 2021; 16 (3) . https://dx.doi.org/10.2174/1574886315666201005103142
DOI https://dx.doi.org/10.2174/1574886315666201005103142 |
Print ISSN 1574-8863 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3911 |
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