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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article (Mini-Review)

Cyclotriphosphazene-based Derivatives for Antibacterial Applications: An Update on Recent Advances

Author(s): Xiqi Su, Le Wang*, JingHua Xie, XiaoHui Liu and Helena Tomás

Volume 25 , Issue 2 , 2021

Published on: 01 October, 2020

Page: [301 - 314] Pages: 14

DOI: 10.2174/1385272824999201001154127

Price: $65


As a phosphorus scaffold, hexachlorocyclotriphosphazene (HCCP) is widely used for the synthesis of varieties of derivatives, including metal-binding complexes and several unique organometallic compounds, which exhibit potential catalytic, flame retardant and biological activities. Some metal-binding HCCP derivatives have shown antibacterial activities as free ligands and metal complexes. These derivatives can also serve as building blocks for the formation of antibacterial metal-containing polymers. This mini-review is focused on the design and development of HCCP derivatives as potential antibacterial agents with representative examples as well as antibacterial mechanisms from recent years.

Keywords: Hexachlorocyclotriphosphazene(HCCP), antibacterial, antibacterial mechanism, metal, ligand, polymer.

Graphical Abstract
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