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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Mini-Review Article

The Functional Impact of Alternative Splicing and Single Nucleotide Polymorphisms in Rheumatoid Arthritis

Author(s): R. Kowshik Aravilli, S. Laveen Vikram and V. Kohila*

Volume 22, Issue 8, 2021

Published on: 01 October, 2020

Page: [1014 - 1029] Pages: 16

DOI: 10.2174/1389201021666201001142416

Price: $65

Abstract

Advances in genomics and proteomics aid the identification of genes associated with various diseases. Genome-Wide Association Studies (GWAS) have identified multiple loci as risk alleles for susceptibility to Rheumatoid Arthritis (RA). A bisection of RA risk can be attributed to genetic factors. Over 100 associated genetic loci that encompass immune regulatory factors have been found to be linked with RA. Aberrant Single Nucleotide Polymorphisms (SNPs) and alternative splicing mechanisms in such loci induce RA. These aberrations are viewed as potential therapeutic targets due to their association with a multitude of diseases. This review presents a few imperious genes whose alterations can cause severe bone deformities culminating in RA.

Keywords: Rheumatoid arthritis, alternative splicing, bone deformation, inflammation, single nucleotide polymorphisms, autoimmunity.

Graphical Abstract
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