Abstract
Aim: The present work provides a fast, simple, accurate, and inexpensive analytical method for the determination of Linagliptin (anti-diabetic drug).
Methods: The analysis was performed using a square wave adsorptive anodic stripping voltammetric technique (SWAASV) and glassy carbon electrode (GCE) as a working electrode. The experimental and instrumental parameters were studied and discussed to ensure the validity of the method.
Results: The method has a very good linearity (R2 = 0.9984), wide concentration range (0.189 - 2.268 μg mL-1), low detection limit of 0.052 μg mL-1 and low quantitation limit of 0.172 μg mL-1.
Conclusion: Linagliptin was identified successfully using the proposed method in pharmaceutical formulations, spiked human urine and plasma with 99.67, 91.96, and 92.78% recovery, respectively, and the results obtained were compared with other reported methods.
Keywords: Linagliptin, glassy carbon electrode, Square wave voltammetry, Pharmaceutical, pure form, biological fluids.
Current Pharmaceutical Design
Title:A Glassy Carbon Electrode for the Determination of Linagliptin, an Antidiabetic Drug in Pure Form, Tablets and Some Biological Fluids by Adsorptive Stripping Voltammetry
Volume: 27 Issue: 20
Author(s): Ahmed A. Gahlan, Ahmed M. Haredy*, Sayed M. Derayea, Mahmoud A. Omar and Gamal A. Saleh
Affiliation:
- Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut,Egypt
Keywords: Linagliptin, glassy carbon electrode, Square wave voltammetry, Pharmaceutical, pure form, biological fluids.
Abstract:
Aim: The present work provides a fast, simple, accurate, and inexpensive analytical method for the determination of Linagliptin (anti-diabetic drug).
Methods: The analysis was performed using a square wave adsorptive anodic stripping voltammetric technique (SWAASV) and glassy carbon electrode (GCE) as a working electrode. The experimental and instrumental parameters were studied and discussed to ensure the validity of the method.
Results: The method has a very good linearity (R2 = 0.9984), wide concentration range (0.189 - 2.268 μg mL-1), low detection limit of 0.052 μg mL-1 and low quantitation limit of 0.172 μg mL-1.
Conclusion: Linagliptin was identified successfully using the proposed method in pharmaceutical formulations, spiked human urine and plasma with 99.67, 91.96, and 92.78% recovery, respectively, and the results obtained were compared with other reported methods.
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Cite this article as:
Gahlan A. Ahmed , Haredy M. Ahmed *, Derayea M. Sayed, Omar A. Mahmoud and Saleh A. Gamal , A Glassy Carbon Electrode for the Determination of Linagliptin, an Antidiabetic Drug in Pure Form, Tablets and Some Biological Fluids by Adsorptive Stripping Voltammetry, Current Pharmaceutical Design 2021; 27(20) . https://dx.doi.org/10.2174/1381612826666200925123245
DOI https://dx.doi.org/10.2174/1381612826666200925123245 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |

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