A Glassy Carbon Electrode for the Determination of Linagliptin, an Antidiabetic Drug in Pure Form, Tablets and Some Biological Fluids by Adsorptive Stripping Voltammetry

Title:A Glassy Carbon Electrode for the Determination of Linagliptin, an Antidiabetic Drug in Pure Form, Tablets and Some Biological Fluids by Adsorptive Stripping Voltammetry

Volume: 27 Issue: 20

Author(s): Ahmed A. Gahlan, Ahmed M. Haredy*, Sayed M. Derayea, Mahmoud A. Omar and Gamal A. Saleh

Affiliation:

• Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut,Egypt

Keywords: Linagliptin, glassy carbon electrode, Square wave voltammetry, Pharmaceutical, pure form, biological fluids.

Abstract:

Aim: The present work provides a fast, simple, accurate, and inexpensive analytical method for the determination of Linagliptin (anti-diabetic drug).

Methods: The analysis was performed using a square wave adsorptive anodic stripping voltammetric technique (SWAASV) and glassy carbon electrode (GCE) as a working electrode. The experimental and instrumental parameters were studied and discussed to ensure the validity of the method.

Results: The method has a very good linearity (R² = 0.9984), wide concentration range (0.189 - 2.268 μg mL^-1), low detection limit of 0.052 μg mL^-1 and low quantitation limit of 0.172 μg mL^-1.

Conclusion: Linagliptin was identified successfully using the proposed method in pharmaceutical formulations, spiked human urine and plasma with 99.67, 91.96, and 92.78% recovery, respectively, and the results obtained were compared with other reported methods.

Cite this article as:

Gahlan A. Ahmed , Haredy M. Ahmed *, Derayea M. Sayed, Omar A. Mahmoud and Saleh A. Gamal , A Glassy Carbon Electrode for the Determination of Linagliptin, an Antidiabetic Drug in Pure Form, Tablets and Some Biological Fluids by Adsorptive Stripping Voltammetry, Current Pharmaceutical Design 2021; 27(20) . https://dx.doi.org/10.2174/1381612826666200925123245