Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways

Title:Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways

Volume: 19 Issue: 6

Author(s): Aisha Siddiqui, Sayeed Akhtar*, Zahoor Shah, Iekhsan Othman and Yatinesh Kumari*

Affiliation:

• Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha-21974,Saudi Arabia

• Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, 47500 Selangor,Malaysia

Keywords: Alzheimer's Diseases, 5-lipoxygenase, Neuro Inflammation, Neurodegeneration, Lipid Molecule, Arachidonic Acid.

Abstract: It is a known fact that inflammation affects several physiological processes, including the functioning of the central nervous system. Additionally, impairment of lipid mechanisms/pathways have been associated with a number of neurodegenerative disorders and Alzheimer’s Disease (AD) is one of them. However, much attention has been given to the link between tau and beta- amyloid hypothesis in AD pathogenesis/prognosis. Increasing evidences suggest that biologically active lipid molecules could influence the pathophysiology of AD via a different mechanism of inflammation. This review intends to highlight the role of inflammatory responses in the context of AD with the emphasis on biochemical pathways of lipid metabolism enzyme, 5-lipoxygenase (5- LO).

Cite this article as:

Siddiqui Aisha , Akhtar Sayeed *, Shah Zahoor , Othman Iekhsan and Kumari Yatinesh *, Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways, Current Neuropharmacology 2021; 19(6) . https://dx.doi.org/10.2174/1570159X18666200924122732