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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Parallel Processing of Microwave-Assisted Organic Transformations

Author(s): C. Oliver Kappe and Mitra Matloobi

Volume 10, Issue 9, 2007

Page: [735 - 750] Pages: 16

DOI: 10.2174/138620707783018496

Price: $65


Microwave-assisted organic synthesis is an enabling technology that has been exploited for a variety of applications including medicinal chemistry/drug discovery projects where speed is often a critical factor. In this review, applications of microwave-assisted organic synthesis employing a parallel processing regime are summarized. Examples include parallel synthesis in domestic microwave ovens, the use of specialized multivessel rotors and microtiter plates in dedicated multimode microwave reactors, and applications of SPOT synthesis on cellulose matrices.

Keywords: Parallel synthesis, microwave irradiation, multivessel rotors, microtiter plates, high-throughput synthesis

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