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Current Drug Delivery


ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

General Research Article

Improved Drug Delivery System for Cancer Treatment by D-Glucose Conjugation with Eugenol From Natural Product

Author(s): Mas Amira Idayu Abdul Razak, Haslinda Abdul Hamid, Raja Nor Izawati Raja Othman, Shaik Alaudeen Mohd Moktar and Azizi Miskon*

Volume 18 , Issue 3 , 2021

Published on: 17 September, 2020

Page: [312 - 322] Pages: 11

DOI: 10.2174/1567201817666200917123639

Price: $65


Introduction: Bioconjugations are swiftly progressing and are being applied to solve several limitations of conventional Drug Delivery Systems (DDS) such as lack of water solubility, non-specific, and poor bioavailability. The main goals of DDS are to achieve greater drug effectiveness and minimize toxicity to the healthy tissues.

Objectives and Methods: In this study, D-glucose was conjugated with eugenol to target the cancer cells. To identify the implication of the anticancer effect, osteosarcoma (K7M2) cells were cultured and the anti-proliferative effect was performed using MTT [3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide assay] test in order to evaluate the viability and toxicity on cells with various concentrations of eugenol and D-glucose-eugenol conjugate in 24-hour incubation.

Results: It was found that, the successful confirmation of the conjugation between D-glucose and eugenol was obtained by 1H NMR spectroscopy. MTT assay showed inhibitory concentration (IC50 value) of D-glucose-eugenol was at 96.2 μg/ml and the decreased of osteosarcoma cell survival was 48%.

Conclucion: These findings strongly indicate that K7M2 cells would be affected by toxicity of Dglucose- eugenol. Therefore, the present study suggests that D-glucose-eugenol has high potential to act as an anti-proliferative agent who may promise a new modality or approach as the drug delivery treatment for cancer or chemotherapeutic agent.

Keywords: Conjugation, D-glucose, eugenol, Drug Delivery Systems (DDS), cancer treatment, osteosarcoma (K7M2).

Graphical Abstract
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