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Review Article

可生物降解的纳米颗粒：一种最新的方法和应用

卷 21, 期 16, 2020

页: [1722 - 1732] 页: 11

弟呕挨: 10.2174/1389450121666200916091659

价格: $65

摘要

可生物降解的纳米颗粒（NPs）是用于药物分子给药的新型载体。可生物降解的纳米颗粒由于其特殊功能（例如靶向药物递送，提高的生物利用度和更好的治疗效果，以恒定速率给药）最近变得流行。聚合物NP是非常小的聚合物胶体元素，其中感兴趣的药物可以被封装或掺入其聚合物网络中，或者被缀合或吸附在该层上。在纳米粒子的制造中使用了各种聚合物，一些常用的聚合物是试剂，壳聚糖，纤维素，明胶，麦醇溶蛋白，聚乳酸，聚乳酸-乙醇酸共聚物和支链淀粉。纳米颗粒已被逐步探索用于将靶向的ARV递送至感染HIV的细胞，并已进行了延长的动力学释放。嵌入该系统中的药物可以提供更好的效果，减少药物的耐药性，减少全身毒性和症状，还可以增强患者的依从性。本综述着重介绍了可生物降解的纳米颗粒，各种聚合物的常用制造方法及其在抗逆转录病毒疗法中的应用。此外，还介绍了用于检查纳米颗粒纯度的通用评估参数，正在进行的和最近结束的临床试验以及各种研究人员提供的专利，以及可生物降解NP在创新药物输送系统中的未来应用。可生物降解的NPs是用于管理包括抗逆转录病毒药物在内的多种药物的有前途的系统，因此可生物降解的纳米颗粒可在未来用于治疗多种疾病和病症。

关键词: 抗逆转录病毒疗法，可生物降解的纳米颗粒，临床研究，未来影响，制造方法，专利，使用的聚合物。

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