Generic placeholder image



ISSN (Print): 2666-7967
ISSN (Online): 2666-7975

Letter Article

Utilizing Zebrafish Animal Model as a Helping Hand for COVID-19 Infection

Author(s): Yashbir Singh*, Heenaben Patel, Amit Chaudhary and S. Deepa

Volume 2, Issue 2, 2021

Published on: 15 September, 2020

Page: [272 - 274] Pages: 3

DOI: 10.2174/2666796701999200915144017


Background: The Zebrafish animal model has the potential use to study COVID19 infection in-depth due to its genetic similarity with humans. It has antiviral property. As we know, SARS-CoV-2 is an RNA virus, which has a high genetic mutation rate, therefore difficult to understand its structure. It is a great way to understand the genetic dynamics of Zebrafish, which is related to orthologous human genes.

Objective: The study aims to validate the possible role of the Zebrafish animal model in the COVID19 diagnosis.

Methods: We have reviewed a lot of literature towards the Zebrafish model and tried to explore the possible connection in the diagnosis of COVID19.

Result: We observed a very close bridge between the Zebrafish model and COVID19 towards possible drug discovery diagnosis.

Conclusion: This research will be helpful to unlock the mechanism clues, finding new therapeutic targets, and understanding adaptability to host.

Keywords: Pandemic, COVID19, zebrafish, drug discovery, machine learning, therapeutic target.

Lessman CA. The developing zebrafish (Danio rerio): a vertebrate model for high-throughput screening of chemical libraries. Birth Defects Res C Embryo Today 2011; 93(3): 268-80.
[] [PMID: 21932435]
Howe K, Clark MD, Torroja CF, et al. The zebrafish reference genome sequence and its relationship to the human genome. Nature 2013; 496(7446): 498-503.
[] [PMID: 23594743]
Silva C. Zebrafish model in the development of COVID-19 rapid test. Ars Veterinaria 2020; 36(1): 3-5.
Galindo-Villegas J. The zebrafish disease and drug screening model: a strong ally against COVID-19 frontiers in pharmacology. Front Pharmacol 2020; 11: 680.
Gabor KA, Goody MF, Mowel WK, et al. Influenza A virus infection in zebrafish recapitulates mammalian infection and sensitivity to anti-influenza drug treatment. Dis Model Mech 2014; 7(11): 1227-37.
[] [PMID: 25190709]
MacRae CA, Peterson RT. Zebrafish as tools for drug discovery. Nat Rev Drug Discov 2015; 14(10): 721-31.
[] [PMID: 26361349]
Langevin C, van der Aa LM, Houel A, et al. Zebrafish ISG15 exerts a strong antiviral activity against RNA and DNA viruses and regulates the interferon response. J Virol 2013; 87(18): 10025-36.
[] [PMID: 23824820]
Summar ML, Candice F, Judy LA. Ultraporous nanofiber mats and uses thereofJapanese Patent JP2017200940A, 2017.
Patel JP, Zou G, Hsu SL, et al. Path to achieving molecular dispersion in adense reactive mixture. J Polym Sci, B, Polym Phys 2015; 53: 1519-26.
Patel JP, Hsu SL, Deshmukh S, et al. An analysis of the role of non-reactive plasticizers in the crosslinking reactions of phenolic resins. J Polym Sci, B, Polym Phys 2016; 55: 206-13.
Patel JP, Hsu SL, Deshmukh S, et al. An analysis of the role of reactive plasticizers in the crosslinking reactions of phenolic resins. Polymer (Guildf) 2016; 107: 12-8.
Singh Y, Srivastava S, Tripathi YJR. A review report on newer advancement in bioisosteric replacement in drug design. IJPSR 2015; 6(5): 939-47.
Singh Y, Shakyawar D, Hu W. An automated method for detecting the scar tissue in the left ventricular endocardial wall using deep learning approach. Curr Med Imaging 2020; 16(3): 206-13.
[] [PMID: 32133950]
Singh Y, Shakyawar D, Hu W. Non-ischemic endocardial scar geometric remodeling toward topological machine learning. J Eng Med 2020; 234(9): 1.

© 2022 Bentham Science Publishers | Privacy Policy