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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Research Article

A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles

Author(s): Alaa A.A. Aljabali*, Lorca Alzoubi, Yassmen Hamzat, Alaa Alqudah, Mohammad A. Obeid, Mazhar S. Al Zoubi, Raed M. Ennab, Walhan Alshaer, Khaled Albatayneh, Bahaa Al-Trad, Dana A. Alqudah, Dinesh Kumar Chellappan, Gaurav Gupta, Murtaza M. Tambuwala, Dua Kamal and David J. Evans

Volume 24, Issue 10, 2021

Published on: 14 September, 2020

Page: [1557 - 1571] Pages: 15

DOI: 10.2174/1386207323666200914110012

Price: $65

Abstract

Background: Virus nanoparticles have been extensively studied over the past decades for theranostics applications. Viruses are well-characterized, naturally occurring nanoparticles that can be produced in high quantity with a high degree of similarity in both structure and composition.

Objectives: The plant virus Cowpea Mosaic Virus (CPMV) has been innovatively used as a nanoscaffold. Utilization of the internal cavity of empty Virus-Like Particles (VLPs) for the inclusion of therapeutics within the capsid has opened many opportunities in drug delivery and imaging applications.

Methods: The encapsidation of magnetic materials and anticancer drugs was achieved. SuperscriptCPMV denotes molecules attached to the external surface of CPMV and CPMVSubscript denotes molecules within the interior of the capsid.

Results: Here, the generation of novel VLPs incorporating iron-platinum nanoparticles TCPMVFePt and cisplatin (Cis) (TCPMVCis) is reported. TCPMVCis exhibited a cytotoxic IC50 of TCPMVCis on both A549 and MDA-MB-231 cell lines of 1.8 μM and 3.9 μM, respectively after 72 hours of incubation. The TCPMVFePt were prepared as potential MRI contrast agents.

Conclusion: Cisplatin loaded VLP (TCPMVCis) is shown to enhance cisplatin cytotoxicity in cancer cell lines with its potency increased by 2.3-folds.

Keywords: Virus-like particles, viruses, bioconjugation, drug delivery, cisplatin, nanomedicine.


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