Fluorinated-NHC Transition Metal Complexes: Leading Characters as Potential Anticancer Metallodrugs

Title:Fluorinated-NHC Transition Metal Complexes: Leading Characters as Potential Anticancer Metallodrugs

Volume: 21 Issue: 8

Author(s): Ernesto Rufino-Felipe, Raúl Colorado-Peralta, Viviana Reyes-Márquez , Hugo Valdés and David Morales-Morales*

Affiliation:

• Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, Coyoacan, Ciudad de Mexico, C.P. 04510,Mexico

Keywords: Cytotoxicity, fluorinated complexes, NHC complexes, cancer, N-heterocyclic Carbene (NHC), fluorine, metallodrugs.

Abstract: In the last 20 years, N-Heterocyclic Carbene (NHC) ligands have been ubiquitous in biological and medicinal chemistry. Part of their success lies in the tremendous number of topologies that can be synthesized and thus finely tuned that have been described so far. This is particularly true in the case of those derivatives, including fluorine or fluorinated fragments on their NHC moieties, gaining much attention due to their enhanced biological properties and turning them into excellent candidates for the development of novel metallodrugs. Thus, this review summarizes the development that fluorinated-NHC transition metal complexes have had and their impact on cancer treatment.

Cite this article as:

Rufino-Felipe Ernesto , Colorado-Peralta Raúl , Reyes-Márquez Viviana , Valdés Hugo and Morales-Morales David *, Fluorinated-NHC Transition Metal Complexes: Leading Characters as Potential Anticancer Metallodrugs, Anti-Cancer Agents in Medicinal Chemistry 2021; 21(8) . https://dx.doi.org/10.2174/1871520620666200908103452