Abstract
Stroke is thought to be a multifactorial disease that is affected by several environmental factors and genetic variants. In 2002, a candidate locus for stroke (STRK1) was identified with a significant logarithm of odds (LOD) score at 5q12 in Caucasians, and in 2003, the PDE4D gene was subsequently identified as a susceptibility gene at this locus. Some investigators have recently examined whether polymorphisms in the PDE4D gene are associated with stroke in population studies. Some of these studies have reported the polymorphisms to be associated with a risk of stroke, while others have reported the exact opposite. These discrepancies have been attributed to racial differences or differences in methodologies and analyses. In 2006, a powerful method for isolating the susceptibility region at 5q12 was reported in a haplotype-based case-control study. In the present paper, we review both current issues and progress in the isolation of susceptibility genes for ischemic stroke, with particular emphasis on the PDE4D gene in the STRK1 region of 5q12.
Keywords: Stroke, cerebral infarction, PDE4D gene, case-control study, mutation, polymorphism
Current Medicinal Chemistry
Title: PDE4D Gene in the STRK1 Region on 5q12: Susceptibility Gene for Ischemic Stroke
Volume: 14 Issue: 30
Author(s): Tomohiro Nakayama, Satoshi Asai, Naoyuki Sato and Masayoshi Soma
Affiliation:
Keywords: Stroke, cerebral infarction, PDE4D gene, case-control study, mutation, polymorphism
Abstract: Stroke is thought to be a multifactorial disease that is affected by several environmental factors and genetic variants. In 2002, a candidate locus for stroke (STRK1) was identified with a significant logarithm of odds (LOD) score at 5q12 in Caucasians, and in 2003, the PDE4D gene was subsequently identified as a susceptibility gene at this locus. Some investigators have recently examined whether polymorphisms in the PDE4D gene are associated with stroke in population studies. Some of these studies have reported the polymorphisms to be associated with a risk of stroke, while others have reported the exact opposite. These discrepancies have been attributed to racial differences or differences in methodologies and analyses. In 2006, a powerful method for isolating the susceptibility region at 5q12 was reported in a haplotype-based case-control study. In the present paper, we review both current issues and progress in the isolation of susceptibility genes for ischemic stroke, with particular emphasis on the PDE4D gene in the STRK1 region of 5q12.
Export Options
About this article
Cite this article as:
Nakayama Tomohiro, Asai Satoshi, Sato Naoyuki and Soma Masayoshi, PDE4D Gene in the STRK1 Region on 5q12: Susceptibility Gene for Ischemic Stroke, Current Medicinal Chemistry 2007; 14 (30) . https://dx.doi.org/10.2174/092986707782793871
DOI https://dx.doi.org/10.2174/092986707782793871 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Antiplatelet Therapy And Percutaneous Coronary Interventions
Current Cardiology Reviews Is the Hepatic Factor a miRNA that Maintains the Integrity of Pulmonary Microvasculature by Inhibiting the Vascular Endothelial Growth Factor?
Current Cardiology Reviews Preoperative Functional Magnetic Resonance Imaging (fMRI) and Transcranial Magnetic Stimulation (TMS)
Current Medical Imaging Protein Kinase C – Possible Therapeutic Target to Treat Cardiovascular Diseases
Cardiovascular & Hematological Disorders-Drug Targets Emerging Role of Bone Morphogenetic Proteins as a Context Dependent Pro-Angiogenic Cue
Current Angiogenesis (Discontinued) Why and how do Microbubbles Enhance the Effectiveness of Diagnostic and Therapeutic Interventions in Cerebrovascular Disease?
Current Pharmaceutical Design HHT: A Rare Disease with A Broad Spectrum of Clinical Aspects
Current Pharmaceutical Design Vasculogenesis: Making Pipes for the Cardiovascular Plumbing
Current Angiogenesis (Discontinued) Treatment of Heyde's Syndrome by Aortic Valve Replacement
Current Cardiology Reviews HspB5/αB-Crystallin: Properties and Current Progress in Neuropathy
Current Neurovascular Research Multitarget Network Strategies to Influence Memory and Forgetting: The Ras/Mapk Pathway as a Novel Option
Mini-Reviews in Medicinal Chemistry Cutaneomeningospinal Angiomatosis (Cobb Syndrome) in a Young Patient
CNS & Neurological Disorders - Drug Targets Remodelling of the Ca2+ Toolkit in Tumor Endothelium as a Crucial Responsible for the Resistance to Anticancer Therapies
Current Signal Transduction Therapy Antiepileptic Drug Monotherapy: The Initial Approach in Epilepsy Management
Current Neuropharmacology Hereditary Haemorrhagic Teleangiectasia: Diagnostic Imaging of Visceral Involvement
Current Pharmaceutical Design Novel Application of Plasma Treatment for Pharmaceutical and Biomedical Engineering
Current Drug Discovery Technologies Idiopathic Transverse Myelitis and Neuromyelitis Optica: Clinical Profiles,Pathophysiology and Therapeutic Choices
Current Neuropharmacology Acute Antithrombotic Treatment of Ischemic Stroke
Current Vascular Pharmacology A Survey on Synthesis Processes of Structured Materials for Biomedical Applications: Iron-based Magnetic Nanoparticles, Polymeric Materials and Polymerization Processes
Current Pharmaceutical Design Basis for the Application of Analytical Models of the Bloch NMR Flow Equations for Functional Magnetic Resonance Imaging (fMRI): A Review
Recent Patents on Medical Imaging