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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Review Article

Decoding the Inter-Relationship between Sleep Disorders and Alzheimer’s Disease Pathogenesis

Author(s): Zeba Mueed, Pankaj Kumar Rai, Mohammad Amjad Kamal and Nitesh Kumar Poddar*

Volume 20 , Issue 8 , 2021

Published on: 03 September, 2020

Page: [723 - 735] Pages: 13

DOI: 10.2174/1871527319666200903161249

Price: $65

Abstract

Alzheimer’s Disease (AD), characterized by abnormally phosphorylated tau, Paired Helical Filaments (PHFs), Neurofibrillary Tangles (NFTs), deregulated mammalian Target Of Rapamycin (mTOR), and Aβ deposits, is a multifactorial disease with sleep disorders being one of the causative agents. Therefore, we have reviewed the literature and have tried to decode the existence of positive feedback, reciprocal and a bidirectional relationship allying between sleep disturbances and AD. Much light has been thrown on the role of tau pathology and amyloid pathology in sleep pathology and its association with AD pathology. We have also discussed the role of melatonin in regulating sleep disorders and AD. The neuroprotective effect of melatonin via inhibiting tau hyperphosphorylation and Aβ deposition has also been discussed. Moreover, astrocytes involvement in aggravating AD has also been highlighted in this review. Several therapeutic approaches aimed at improving both sleep disorders and AD have been duly discussed such as administration of antidepressants and antihistamines, immunotherapy, metal chelators, melatonin supplementation, light therapy and physical activity. Despite consistent efforts, the complete etiology concerning sleep disorder and AD is still unclear. Therefore, further research is needed to unravel the mechanism involved and also to develop strategies that may help in obstructing AD in its preclinical stage.

Keywords: Alzheimer's Disease (AD), tau, amyloid, circadian rhythm, sleep disturbances, melatonin, astrocytes.

Graphical Abstract

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