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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Functional Role of Glycosphingolipids in Cancer

Author(s): Changping Zheng, Marco Terreni, Matthieu Sollogoub and Yongmin Zhang*

Volume 28 , Issue 20 , 2021

Published on: 31 August, 2020

Page: [3913 - 3924] Pages: 12

DOI: 10.2174/0929867327666200831132200

Price: $65


Glycosphingolipids (GSLs) are ubiquitous components on animal cell membranes, and exposed on the outer surface. Various studies have demonstrated that they play key roles in cell proliferation, adhesion, motility and differentiation. Usually, the specific types of GSLs are expressed more highly in tumors than in normal tissues, which are known as tumorassociated antigens. It has been revealed that most tumor cells show altered GSLs patterns on their surface, abnormal GSLs signaling and biosynthesis, which together play a major role in tumor development. Tumor-associated GSL antigens have been used in the development of antitumor vaccines. There is no doubt that GSLs play a crucial role in tumor progression and would be a promising target for cancer treatment.

Keywords: Glycosphingolipids, tumor-associated antigens, GSL signaling, carbohydrates, medicinal chemistry, cancer.

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