Abstract
Background: Prevalence and the risk of common antiphospholipid antibodies (aPLs), such as lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2-glycoprotein I (β2-GPI) antibodies, in preeclampsia is a matter of debate. Recently, interests have expanded in evaluating the risks of presenting non-classic aPLs in preeclampsia patients.
Objective: The objective of this case-control study was to evaluate some hematological parameters besides assessing the presence of anti-annexin A5 and anti phosphatidylinositol (aPI) antibodies in preeclampsia patients compared to non-preeclampsia subjects.
Methods: From two hospitals in Malaysia, a total of 84 subjects were recruited in this case-control study, including 42 preeclampsia and 42 age-matched non-preeclampsia subjects. Some hematological parameters [i.e., hemoglobin, total white blood cell, platelet, prothrombin time, and activated partial thromboplastin time (APTT)] were assessed besides screening for anti-annexin A5 and aPI antibodies.
Results: Among the hematological parameters, APTT was significantly high in mild preeclampsia when compared to severe preeclampsia subjects (p=0.007). IgG anti-annexin A5 antibody was detected in a single preeclampsia subject only (2.4%) and none in non-preeclampsia subjects.
Conclusion: Because of the low prevalence, non-classic aPLs should not be considered as a risk factor in developing preeclampsia and it is not justifiable to consider them as a routine assay in pregnant women.
Keywords: Preeclampsia, hematological, activated partial thromboplastin time, antiphospholipid, anti-annexin A5, antiphosphatidylinositol.
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RARE CASES IN GYNECOLOGY-OBSTETRICS
With the development of diagnostic and therapeutic techniques (such as ART techniques) and the immersion of new pathologies (such as COVID19), we are witnessing an increase in the incidence of pathologies that were previously described as rare or exceptional. the practitioner sometimes confronts difficult situations in these cases in diagnostic ...read more
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