Login Register Cart 0
Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
General Research Article

Effect of Capsinoids Supplementation on Fat Oxidation and Muscle Glycogen Restoration During Post-exercise Recovery in Humans

Author(s): Su-Fen Liao, Mallikarjuna Korivi, Jung-Piao Tsao, Chun-Ching Huang, Chia-Chen Chang and I-Shiung Cheng*

Volume 27, Issue 7, 2021

Published on: 23 August, 2020

Page: [981 - 988] Pages: 8

DOI: 10.2174/1381612826666200824104856

Price: $65

Abstract

Background: Capsinoids (CSN), the novel non-pungent capsaicin analogs have been reported to promote metabolic health and exercise tolerance. However, the effect of CSN on fat oxidation and changes in skeletal muscle glycogen levels during post-exercise recovery has not been investigated in humans.

Purpose: We examined the effect of CSN supplementation on energy reliance, glycogen resynthesis and molecular proteins in the skeletal muscle of young adults during post-exercise recovery.

Methods: In this crossover-designed study, nine healthy adult male volunteers (aged 21.4±0.2 years, BMI 21.9±1.3 kg/m2) completed a 60-min cycling exercise at 70% VO2max. Participants consumed either CSN (12 mg, single dosage) or placebo capsules with a high-carbohydrate meal (2 g carb/kg bodyweight) immediately after exercise. Biopsied muscle samples (vastus lateralis), blood, and gaseous samples were obtained during 3h postexercise recovery period.

Results: We found that oral CSN supplementation right after exercise significantly altered the energy reliance on fat oxidation during recovery. This was evidenced by lower respiratory exchange ratio (RER) and higher fat oxidation rate in CSN trial. Despite this, acute CSN dosage does not contribute in enhancing the glycogen replenishment in skeletal muscle during 3h recovery. We identified no significant differences in postprandial glucose and insulin area under the curve in both trials. Western blot data showed an increased muscle GLUT4 expression, but no significant response of p-Akt/Akt ratio with CSN during post-exercise recovery.

Conclusion: Our findings conclude that acute CSN intake could change energy reliance on fat oxidation but is unable to enhance muscle glycogen resynthesis during post-exercise recovery. Thus, ergogenic properties of CSN in relevance to muscle glycogen restoration following exercise needs to be further investigated in young adults.

Keywords: Nutraceutical supplements, ergogenic aids, substrate oxidation, muscle glycogen, supplementation, capsinoids.

« Previous Next »
[1]
Kobata K, Todo T, Yazawa S, Iwai K, Watanabe T. Novel capsaicinoid-like substances, capsiate and dihydrocapsiate, from the fruits of a nonpungent cultivar, CH-19 Sweet, of pepper (Capsicum annuum L.). J Agric Food Chem 1998; 46(5): 1695-7.
[http://dx.doi.org/10.1021/jf980135c]
[2]
Kawabata F, Inoue N, Masamoto Y, et al. Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice. Biosci Biotechnol Biochem 2009; 73(12): 2690-7.
[http://dx.doi.org/10.1271/bbb.90555] [PMID: 19966466]
[3]
Morita A, Iwasaki Y, Kobata K, et al. Lipophilicity of capsaicinoids and capsinoids influences the multiple activation process of rat TRPV1. Life Sci 2006; 79(24): 2303-10.
[http://dx.doi.org/10.1016/j.lfs.2006.07.024] [PMID: 16950406]
[4]
Ohyama K, Nogusa Y, Suzuki K, Shinoda K, Kajimura S, Bannai M. A combination of exercise and capsinoid supplementation additively suppresses diet-induced obesity by increasing energy expenditure in mice. Am J Physiol Endocrinol Metab 2015; 308(4): E315-23.
[http://dx.doi.org/10.1152/ajpendo.00354.2014] [PMID: 25516550]
[5]
Snitker S, Fujishima Y, Shen H, et al. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr 2009; 89(1): 45-50.
[http://dx.doi.org/10.3945/ajcn.2008.26561] [PMID: 19056576]
[6]
Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite 2012; 59(2): 341-8.
[http://dx.doi.org/10.1016/j.appet.2012.05.015] [PMID: 22634197]
[7]
Sahlin K, Tonkonogi M, Söderlund K. Energy supply and muscle fatigue in humans. Acta Physiol Scand 1998; 162(3): 261-6.
[http://dx.doi.org/10.1046/j.1365-201X.1998.0298f.x] [PMID: 9578371]
[8]
Huang S, Czech MP. The GLUT4 glucose transporter. Cell Metab 2007; 5(4): 237-52.
[http://dx.doi.org/10.1016/j.cmet.2007.03.006] [PMID: 17403369]
[9]
Ivy JL, Kuo CH. Regulation of GLUT4 protein and glycogen synthase during muscle glycogen synthesis after exercise. Acta Physiol Scand 1998; 162(3): 295-304.
[http://dx.doi.org/10.1046/j.1365-201X.1998.0302e.x] [PMID: 9578375]
[10]
Sakamoto K, Holman GD. Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic. Am J Physiol Endocrinol Metab 2008; 295(1): E29-37.
[http://dx.doi.org/10.1152/ajpendo.90331.2008] [PMID: 18477703]
[11]
Thong FS, Bilan PJ, Klip A. The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic. Diabetes 2007; 56(2): 414-23.
[http://dx.doi.org/10.2337/db06-0900] [PMID: 17259386]
[12]
Shin KO, Moritani T. Alterations of autonomic nervous activity and energy metabolism by capsaicin ingestion during aerobic exercise in healthy men. J Nutr Sci Vitaminol (Tokyo) 2007; 53(2): 124-32.
[http://dx.doi.org/10.3177/jnsv.53.124] [PMID: 17615999]
[13]
Josse AR, Sherriffs SS, Holwerda AM, Andrews R, Staples AW, Phillips SM. Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise. Nutr Metab (Lond) 2010; 7(1): 65.
[http://dx.doi.org/10.1186/1743-7075-7-65] [PMID: 20682072]
[14]
Tsao J-P, Liao S-F, Korivi M, et al. Oral conjugated linoleic acid supplementation enhanced glycogen resynthesis in exercised human skeletal muscle. J Sports Sci 2015; 33(9): 915-23.
[http://dx.doi.org/10.1080/02640414.2014.970219] [PMID: 25385360]
[15]
Tsai T-W, Chang C-C, Liao S-F, et al. Effect of green tea extract supplementation on glycogen replenishment in exercised human skeletal muscle. Br J Nutr 2017; 117(10): 1343-50.
[http://dx.doi.org/10.1017/S0007114517001374] [PMID: 28631582]
[16]
Bergstrom J. Muscle electrolytes in man determined by neutron activation analysis on needle biopsy specimens. Scandinavian Journal of Clinical and Laboratory Investigation J Clin Lab Invest 1962; 14(68)
[17]
Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 1983; 55(2): 628-34.
[http://dx.doi.org/10.1152/jappl.1983.55.2.628] [PMID: 6618956]
[18]
Kim J, Park J, Lim K. Nutrition supplements to stimulate lipolysis: A review in relation to endurance exercise capacity. J Nutr Sci Vitaminol (Tokyo) 2016; 62(3): 141-61.
[http://dx.doi.org/10.3177/jnsv.62.141] [PMID: 27465721]
[19]
Poddar K, Kolge S, Bezman L, Mullin GE, Cheskin LJ. Nutraceutical supplements for weight loss: a systematic review. Nutr Clin Pract 2011; 26(5): 539-52.
[http://dx.doi.org/10.1177/0884533611419859] [PMID: 21947637]
[20]
Yoneshiro T, Saito M. Activation and recruitment of brown adipose tissue as anti-obesity regimens in humans. Ann Med 2015; 47(2): 133-41.
[http://dx.doi.org/10.3109/07853890.2014.911595] [PMID: 24901355]
[21]
Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M. Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 2012; 95(4): 845-50.
[http://dx.doi.org/10.3945/ajcn.111.018606] [PMID: 22378725]
[22]
Hawley JA, Burke LM. Carbohydrate availability and training adaptation: effects on cell metabolism. Exerc Sport Sci Rev 2010; 38(4): 152-60.
[http://dx.doi.org/10.1097/JES.0b013e3181f44dd9] [PMID: 20871231]
[23]
Kimber NE, Heigenhauser GJ, Spriet LL, Dyck DJ. Skeletal muscle fat and carbohydrate metabolism during recovery from glycogen-depleting exercise in humans. J Physiol 2003; 548(Pt 3): 919-27.
[http://dx.doi.org/10.1113/jphysiol.2002.031179] [PMID: 12651914]
[24]
Bryant NJ, Govers R, James DE. Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol 2002; 3(4): 267-77.
[http://dx.doi.org/10.1038/nrm782] [PMID: 11994746]
[25]
Samovski D, Su X, Xu Y, Abumrad NA, Stahl PD. Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase. J Lipid Res 2012; 53(4): 709-17.
[http://dx.doi.org/10.1194/jlr.M023424] [PMID: 22315395]
[26]
Lee E-J, Jeon M-S, Kim B-D, et al. Capsiate inhibits ultraviolet B-induced skin inflammation by inhibiting Src family kinases and epidermal growth factor receptor signaling. Free Radic Biol Med 2010; 48(9): 1133-43.
[http://dx.doi.org/10.1016/j.freeradbiomed.2010.01.034] [PMID: 20123015]
[27]
Hong Q, Xia C, Xiangying H, Quan Y. Capsinoids suppress fat accumulation via lipid metabolism. Mol Med Rep 2015; 11(3): 1669-74.
[http://dx.doi.org/10.3892/mmr.2014.2996] [PMID: 25421144]

Rights & Permissions Print Cite
Article Metrics
25
1
World Health Day
© 2024 Bentham Science Publishers | Privacy Policy