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Current Drug Research Reviews


ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

Review Article

Identification of Drug Candidates for Breast Cancer Therapy Through Scaffold Repurposing: A Brief Review

Author(s): Jubie Selvaraj*, Thangavelu Prabha and Neetu Yadav

Volume 13, Issue 1, 2021

Published on: 24 August, 2020

Page: [3 - 15] Pages: 13

DOI: 10.2174/2589977512666200824103019

Price: $65


Conventional drug discovery is a time consuming and expensive expedition with less clinical preference achievement proportion intended for breast cancer therapy. Even if numerous novel approaches to the conformation of drugs have been introduced for breast cancer therapy, they are yet to be implemented in clinical practice. This tempting strategy facilitates a remarkable chance to take the entire benefit of existing drugs. Despite drug repurposing significantly decrease the investigational period and cost, it has got many objections and issues. Scaffold repurposing is an approach that procures a novel significance on the decrepit motto of “to commencement with a pristine drug” . Hence, we move into a probable and nearer approach, the exploitation of scaffolds, which was originally developed for other purposes, including anti-tumor activity. In this review, we summarize different drugs and scaffolds used in breast cancer therapy.

Keywords: Drug repurposing, scaffold, breast cancer, coumarins, statins, NSAIDs, benzimidazole, long-chain fatty acids, niclosamide, biphosphaonates.

Graphical Abstract
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