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Endocrine, Metabolic & Immune Disorders - Drug Targets


ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Case Report

False Positive of 68Ga-DOTATATE PET-CT in a Paraganglioma

Author(s): Benedetta Zampetti, Roberto Attanasio*, Marco Boniardi and Renato Cozzi

Volume 21, Issue 7, 2021

Published on: 21 August, 2020

Page: [1352 - 1355] Pages: 4

DOI: 10.2174/1871530320666200821141256

open access plus


Background: Functional imaging with 68Ga-DOTATATE PET-CT is widely employed to detect both primary and metastatic pheochromocytomas and paragangliomas (PGL), but its results may be occasionally misleading as in the case here reported.

Case Presentation: We report here a 75-year-old woman with an interaortocaval PGL that was diagnosed after a hypertensive crisis occurring during the resection of a kidney tumor. 68Ga-DOTATATE PET-CT disclosed pathologic uptake in the abdomen and at the iliac crest. After the resection of the abdominal tumor, with the histological confirmation of PGL, arterial blood pressure and metanephrine levels were normalized. Genetic testing was negative. Thereafter, the bone lesion increased in size and became painful, requiring multiple medications. A selective biopsy disclosed a metastatic lesion arising from the renal tumor.

Conclusion: The false-positive result of 68Ga-DOTATATE PET-CT is discussed.

Keywords: Paraganglioma, pheochromocytoma, imaging, Ga-DOTA-peptides, bone metastasis, differential diagnosis.

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