Generic placeholder image

Current Hypertension Reviews


ISSN (Print): 1573-4021
ISSN (Online): 1875-6506

General Research Article

Endogenous Bufadienolide, Blood Pressure and Alcohol Withdrawal

Author(s): Vladimir A. Kashkin*, Alexei Y. Egorov, Evgeniy M. Krupitsky and Alexei Y. Bagrov*

Volume 17 , Issue 2 , 2021

Published on: 19 August, 2020

Page: [170 - 173] Pages: 4

DOI: 10.2174/1573402116999200819162306

Price: $65


Background and Objective: Previously, it was demonstrated that marinobufagenin (MBG) is implicated in the development of ethanol withdrawal in rats. It has been shown that ethanol withdrawal is associated with a pressor response in the alcoholics. We hypothesized that elevated levels of sodium pump ligand, MBG, would underline the increase in systolic blood pressure during alcohol withdrawal in humans.

Methods: The cohort included 9 patients with the diagnosis “alcohol dependence syndrome” (F10.(1-3) according to ICD-10). The blood samples for measurement of MBG concentration were collected from the subjects on the first day of withdrawal and after 7 days treatment of the abstinence. Arterial blood pressure was measured via plethysmography at the same time points.

Results: The beginning of the alcoholic abstinence was associated with the rise of arterial blood pressure with enhanced levels of plasma MBG. At day 7 following withdrawal, the systolic blood pressure and MBG levels were decreased to normal values.

Conclusion: The development of alcohol withdrawal is accompanied by an increase in arterial blood pressure, which is associated with increased plasma MBG concentration.

Keywords: Alcohol withdrawal, systolic blood pressure, marinobufagenin, human, endogenous bufadienolide, plasma MBG.

Graphical Abstract
Markou A, Kosten TR, Koob GF. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology 1998; 18(3): 135-74.
[] [PMID: 9471114]
Haddy FJ. Role of dietary salt in hypertension. Life Sci 2006; 79(17): 1585-92.
[] [PMID: 16828490]
Bagrov AY, Bagrov YY, Fedorova OV, Kashkin VA, Patkina NA, Zvartau EE. Endogenous digitalis-like ligands of the sodium pump: possible involvement in mood control and ethanol addiction. Eur Neuropsychopharmacol 2002; 12(1): 1-12.
[] [PMID: 11788235]
Kashkin VA, Zvartau EE, Fedorova OV, Bagrov YY, Lakatta EG, Bagrov AY. Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats. Eur Neuropsychopharmacol 2008; 18(1): 74-7.
[] [PMID: 17683916]
Bagrov AY, Shapiro JI. Endogenous digitalis: pathophysiologic roles and therapeutic applications. Nat Clin Pract Nephrol 2008; 4(7): 378-92.
[] [PMID: 18542120]
Kashkin VA, Bagrov AY, Fedorova OV, et al. Marinobufagenin (MBG) suppression of ethanol-seeking behavior is associated with inhibition of brain cortex Na/K-ATPase in mice. Eur Neuropsychopharmacol 2002; 12(3): 217-23.
[] [PMID: 12007673]
Bagrov YY, Dmitrieva NI, Manusova NB, Zvartau EE, Patkina NA, Bagrov AY. Involvement of endogenous digitalis-like factors in voluntary selection of alcohol by rats. Life Sci 1999; 64(20): PL219-25.
[] [PMID: 10350362]
Di Gennaro C, Vescovi PP, Barilli AL, Giuffredi C, Delsignore R, Montanari A. Sodium sensitivity as a main determinant of blood pressure changes during early withdrawal in heavy alcoholics. Alcohol Clin Exp Res 2002; 26(12): 1810-5.
[] [PMID: 12500104]
Bagrov AY, Fedorova OV, Austin-Lane JL, Dmitrieva RI, Anderson DE. Endogenous marinobufagenin-like immunoreactive factor and Na+, K+ ATPase inhibition during voluntary hypoventilation. Hypertension 1995; 26(5): 781-8.
[] [PMID: 7591018]
Bagrov AY, Fedorova OV. Effects of two putative endogenous digitalis-like factors, marinobufagenin and ouabain, on the Na+, K+-pump in human mesenteric arteries. J Hypertens 1998; 16(12 Pt 2): 1953-8.
[] [PMID: 9886882]
Gonick HC, Ding Y, Vaziri ND, Bagrov AY, Fedorova OV. Simultaneous measurement of marinobufagenin, ouabain, and hypertension-associated protein in various disease states. Clin Exp Hypertens 1998; 20(5-6): 617-27.
[] [PMID: 9682918]
De Witte P. The role of neurotransmitters in alcohol dependence: animal research. Alcohol Alcohol Suppl 1996; 31(1): 13-6.
Dingledine R, McBain CJ. Glutamate and aspartate. In: Siegel GJ, Agranoff BW, Albers RW, Eds. Basic Neurochemistry. Philadelphia, PA: Lippincott-Raven Press 1999; pp. 315-33.
Bagrov AY, Dmitrieva RI, Fedorova OV, Kazakov GP, Roukoyatkina NI, Shpen VM. Endogenous marinobufagenin-like immunoreactive substance. A possible endogenous Na, K-ATPase inhibitor with vasoconstrictor activity. Am J Hypertens 1996; 9(10 Pt 1): 982-90.
[] [PMID: 8896650]
Mehta B, Sereny G. Cardiovascular manifestations during alcohol withdrawal. Mt Sinai J Med 1979; 46(5): 484-5.
[PMID: 317135]
Gheno G, Attard B, Mazzei G. Systemic arterial hypertension in chronic alcoholics. Role of the abstinence syndrome. Minerva Med 1984; 75(19): 1123-8.
[PMID: 6728261]
Nardoni A, Marchetti E, Di Piazza V, Dassi F, Geatti O. Arterial hypertension in alcohol withdrawal syndrome. Minerva Cardioangiol 1986; 34(4): 207-13.
[PMID: 3014377]
Klatsky AL. Blood pressure and alcohol intake. In: Laragh JH, Brenner BM, Eds. Hypertension: Pathophysiology, diagnosis, and management. 2nd ed. New York: Raven Press 1995; pp. 2649-67.
Weinberger MH. Salt sensitivity of blood pressure in humans. Hypertension 1996; 27(3): 481-90.

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy