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Current Diabetes Reviews


ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Review Article

The Mechanisms Involved in Obesity-Induced Male Infertility

Author(s): Hamed Heydari, Rafighe Ghiasi*, Saber Ghaderpour and Rana Keyhanmanesh*

Volume 17, Issue 3, 2021

Published on: 19 August, 2020

Page: [259 - 267] Pages: 9

DOI: 10.2174/1573399816666200819114032

Price: $65


Background: Obesity resulted by imbalance between the intake of energy and energy consumption can lead to growth and metabolic disease development in people. Both in obese men and animal models, several studies indicate that obesity leads to male infertility.

Objective: This review has discussed some mechanisms involved in obesity-induced male infertility.

Methods: Online documents were searched through Science Direct, Pubmed, Scopus, and Google Scholar websites dating from 1959 to recognize studies on obesity, kisspeptin, leptin, and infertility.

Results: Obesity induced elevated inflammatory cytokines and oxidative stress can affect male reproductive functions, including spermatogenesis disorders, reduced male fertility power and hormones involved in the hypothalamus-pituitary-gonadal axis.

Conclusion: There is significant evidence that obesity resulted in male infertility. Obesity has a negative effect on male reproductive function via several mechanisms such as inflammation and oxidative stress.

Keywords: Obesity, inflammation, oxidative stress, male fertility, spermatogenesis, infertility.

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