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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Drug Repurposing in Oncology, an Attractive Opportunity for Novel Combinatorial Regimens

Author(s): Paolo Falvo, Stefania Orecchioni, Stefania Roma, Alessandro Raveane and Francesco Bertolini*

Volume 28 , Issue 11 , 2021

Published on: 17 August, 2020

Page: [2114 - 2136] Pages: 23

DOI: 10.2174/0929867327999200817104912

Price: $65

Abstract

The costs of developing, validating and buying new drugs are dramatically increasing. On the other hand, sobering economies have difficulties in sustaining their healthcare systems, particularly in countries with an elderly population requiring increasing welfare. This conundrum requires immediate action, and a possible option is to study the large, already present arsenal of drugs approved and to use them for innovative therapies. This possibility is particularly interesting in oncology, where the complexity of the cancer genome dictates in most patients a multistep therapeutic approach. In this review, we discuss a) Computational approaches; b) preclinical models; c) currently ongoing or already published clinical trials in the drug repurposing field in oncology; and d) drug repurposing to overcome resistance to previous therapies.

Keywords: Oncology, drug, repurposing, in silico, computational approaches, preclinical models, therapies.


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