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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

针对卵巢癌治疗中的六个癌症标志

卷 20, 期 11, 2020

页: [853 - 867] 页: 15

弟呕挨: 10.2174/1568009620999200816130218

价格: $65

摘要

正常细胞必须克服多种保护机制才能发展为癌细胞。它们的新功能包括生长信号的自给和对抗生长信号的不敏感性，细胞凋亡的逃避，无限的复制潜力，持续的血管生成以及组织的侵袭和转移。这些也被称为癌症的六个标志。对这些过程中涉及的遗传和蛋白质改变的深入了解，使得寻找卵巢癌治疗方法的靶向治疗策略和临床试验设计得以发展。临床上，单用PARP，MEK，VEGF和Chk1 / Chk2抑制剂可观察到更长的无进展生存期。但是，靶向药物的临床疗效仍仅限于特定的分子亚型，尚无试验表明总生存获益。探索新的药物靶标或结合当前可行的生物制剂，有望进一步改善卵巢癌的治疗效果。在这篇综述中，我们打算对涉及卵巢癌致癌作用的分子变化和新兴生物因子以及针对异常途径的联合策略进行全面描述，这可能为将来的卵巢癌治疗提供启示。

关键词: 卵巢癌，癌症标志，靶向治疗，PARP，MEK，VEGF。

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