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Coronaviruses

Editor-in-Chief

ISSN (Print): 2666-7967
ISSN (Online): 2666-7975

Review Article

COVID-19: The Unprecedented Malady- A Holistic Review

Author(s): Viney Chawla and Pooja A. Chawla*

Volume 2 , Issue 2 , 2021

Published on: 13 August, 2020

Page: [172 - 181] Pages: 10

DOI: 10.2174/2666796701999200813191218

Abstract

Background: Coronavirus disease (COVID-19) is spreading rapidly at an unprecedented scale across continents and has emerged as the single biggest risk the world has faced in modern times. Some scientists are comparing it to Spanish flu that created havoc around a century ago. The fear of death by COVID-19 looms large in the world today. The disease has reached devastating proportions since its first reports in December 2019. Doctors are having a difficult time dealing with this challenge and the microbiologists are having sleepless nights to bring about an effective vaccine for this disease. Methods: A number of research and review articles have been exhaustively reviewed. The collected data has been meticulously analyzed and documented.

Conclusion: This paper reviews the different types of coronaviruses, the structure of SARS-CoV-2 responsible for COVID-19, its transmission, and virulence. Further, the article discusses the diagnosis, signs and symptoms like fever, breathlessness, cough, potential loss of taste or smell, sneezing, runny nose, fatigue, headache, sore throat and different treatment approaches including drug repurposing being tried by doctors around the globe that may come handy in the management of disease symptoms. The article describes the use of remdesivir, ribavarin, lopinavir, favipiravir, hydoxychloroquine, chloroquine, and tocilizumab among others in treating COVID-19.

Keywords: Coronavirus disease, COVID-19, chloroquine, diagnosis, SARS CoV-2 structure, pandemic, drug repurposing.

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