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Current Chemical Biology


ISSN (Print): 2212-7968
ISSN (Online): 1872-3136

Review Article

A Recent Review on Drug Modification Using 1,2,3-triazole

Author(s): Adarsh Sahu*, Preeti Sahu and Ramkishore Agrawal

Volume 14, Issue 2, 2020

Page: [71 - 87] Pages: 17

DOI: 10.2174/2212796814999200807214519

Price: $65


Motivated by evidence garnered from literature probing the use of triazoles in drug discovery and development, we reported the utilization of bioisosteric replacement and molecular hybridization in this review. Bio-isosteric replacement has played a significant role in modulating rapid and versatile strategy in synthesizing molecules with multifaceted medicinal properties. Molecular hybridization seeks to conjugate two molecular fragments with diverse applications under very mild reaction conditions. In this regard, 1,2,3-triazole is a well-known scaffold with widespread occurrence in medicinal compounds. It is characterized to have several bioactivities such as anti-microbial, anti-cancer, anti-viral, analgesic, anti- inflammatory effects. Furthermore, the structural features of 1,2,3-triazoles enable it to mimic different functional groups justifying its use as bio-isostere for the synthesis of new molecules of medicinal interest, which we have reported briefly.

Keywords: 1, 2, 3-triazole, molecular hybridization, bioisosteric replacement, amide bond, molecular modification, efficacy.

Graphical Abstract
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