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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Binuclear Metal Complexes in Molecular Recognition and Catalysis

Author(s): Susanne Striegler

Volume 11, Issue 17, 2007

Page: [1543 - 1565] Pages: 23

DOI: 10.2174/138527207782418672

Price: $65

Abstract

Binuclear metal complexes provide an intriguing class of compounds considering both their role in molecular recognition and in catalysis. This review highlights recent developments for the selective recognition of phosphate monoester dianions as diagnostic agents for DNA bulged sequences. The molecular recognition, hydrolysis and oxidation of double-stranded DNA by dinuclear metal complexes are highlighed focusing on recent developments that may lead to new antitumor agents. Additionally, investigations on the allosterism generated by weak host-guest interactions between metalcontaining hosts and metal-containing guests are discussed, and the use of dinuclear copper(II) complexes as tool for selective carbohydrate recognition is emphasized.

Keywords: phosphorylation, Protein tyrosine phosphatases, DNA model, HPNPP cleavage, Oxidation


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