Abstract
Metal complexes that hydrolyze DNA are important, due to their potential use as therapeutic agents, tools in elucidating oligonucleotide structure, and models for naturally-occurring metalloprotein nucleases. Therefore, this review focuses on recent advances in the hydrolysis of DNA and phosphate diester model compounds by non-lanthanide metal complexes.
Keywords: Mononuclear Cobalt Complexes, DNA cleavage, Zinc Complexes, Transition Metal, Dinuclear Iron
Current Organic Chemistry
Title: Hydrolytic DNA Cleavage by Non-Lanthanide Metal Complexes
Volume: 11 Issue: 17
Author(s): Thomas A. Shell and Debra L. Mohler
Affiliation:
Keywords: Mononuclear Cobalt Complexes, DNA cleavage, Zinc Complexes, Transition Metal, Dinuclear Iron
Abstract: Metal complexes that hydrolyze DNA are important, due to their potential use as therapeutic agents, tools in elucidating oligonucleotide structure, and models for naturally-occurring metalloprotein nucleases. Therefore, this review focuses on recent advances in the hydrolysis of DNA and phosphate diester model compounds by non-lanthanide metal complexes.
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Cite this article as:
Shell A. Thomas and Mohler L. Debra, Hydrolytic DNA Cleavage by Non-Lanthanide Metal Complexes, Current Organic Chemistry 2007; 11 (17) . https://dx.doi.org/10.2174/138527207782418654
DOI https://dx.doi.org/10.2174/138527207782418654 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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