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Current Molecular Pharmacology

Editor-in-Chief

ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

Review Article

The Role of microRNAs in Gliomas – Therapeutic Implications

Author(s): Theodora Katsila* and Dimitrios Kardamakis

Volume 14 , Issue 6 , 2021

Published on: 30 July, 2020

Page: [1004 - 1012] Pages: 9

DOI: 10.2174/1874467213666200730115837

Price: $65

Abstract

Background: Malignant gliomas constitute a complex disease phenotype that demands optimum decision-making. Despite being the most common type of primary brain tumors, gliomas are highly heterogeneous when their pathophysiology and response to treatment are considered. Such inter-individual variability also renders differential and early diagnosis extremely difficult. Recent evidence highlight that the gene-environment interplay becomes of fundamental importance in oncogenesis and progression of gliomas.

Objective: To unmask key features of the gliomas disease phenotype and map the inter-individual variability of patients, we explore genotype-to-phenotype associations. Emphasis is put on microRNAs as they regulate gene expression, have been implicated in the pathogenesis of gliomas and may serve as theranostics, empowering non-invasive strategies (circulating free or in exosomes).

Methods: We mined text and omic datasets (as of 2019) and conducted a mixed-method content analysis. A novel framework was developed to meet the aims of our analysis, interrogating data in terms of content and context. We relied on literature data from PubMed/Medline and Scopus, as they are considered the largest abstract and citation databases of peer-reviewed literature. To avoid selection biases, both publicly available and private texts have been assessed. Both percent agreement and Cohen’s kappa statistic have been calculated to avoid biases by SAS® macro MAGREE with multicategorical ratings.

Results: Gliomas serve as a paradigm for multifaceted datasets, despite data sparsity and scarcity. miRNAs and miRNA-based therapeutics are ready for prime time. Exosomal miRNAs empower non-invasive strategies, surpassing circulating free miRNAs, when accuracy and precision are considered.

Conclusion: miRNAs hold promise as theranostics.

Keywords: Theranostics, biomarkers, multi-omics, microRNAs, exosomes, precision oncology.

Graphical Abstract

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