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Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Perspective

Ocular COVID-19: Eyes as a Reservoir to Conceal and Spread SARSCoV- 2

Author(s): Abdul Mannan Baig*, Saara Ahmad, Areeba Khaleeq, Hamna Rafique, Shafiqa Rajput, Mehaer Angez, Ayesha Hameed, Talha Nawaz and Preet Katyara

Volume 21, Issue 4, 2021

Published on: 29 July, 2020

Page: [480 - 483] Pages: 4

DOI: 10.2174/1871526520999200729182242

Abstract

Ocular tissues can serve as a reservoir for the SARS-CoV-2 virus which can not only cause conjunctivitis but also serve as a source of infection transmission to others. Additionally, the eye and its tear drainage apparatus can track the SARS-CoV-2 from the eye into the respiratory tract of the patient. The potential ocular presence of the SARS-CoV-2 in the eye of a patient can target ACE2 receptors in the endothelium of the conjunctival vessels and use the lacrimal sac a potential space to evade immune detection and clinical isolation. The recently reported case of COVID-19 after the acquisition of SARS-CoV-2 from a COVID-19 patient should alert the healthcare professionals dealing with COVID-19 patients that wearing masks alone cannot guarantee protection against infection transmission. Further studies, like isolation of SARS-CoV-2 from the eyes of patients with COVID-19, are needed to identify the eyes as a potential source of SARS-CoV-2 infection transmission.

Keywords: COVID-19, SARS-CoV-2, ACE2 receptors, ocular viral infections, conjunctivitis, respiratory.

Graphical Abstract
[1]
Coronavirus Update (Live): 9,985,626 Cases and 498,669 Deaths from COVID-19 Virus Pandemic - Worldometer. Available from: https://www.worldometers.info/coronavirus/.
[2]
Cui, J.; Li, F.; Shi, Z-L. Origin and evolution of pathogenic coronaviruses. Nat. Rev. Microbiol., 2019, 17(3), 181-192.
[http://dx.doi.org/10.1038/s41579-018-0118-9] [PMID: 30531947]
[3]
Lin, Q.; Zhao, S.; Gao, D.; Lou, Y.; Yang, S.; Musa, S.S.; Wang, M.H.; Cai, Y.; Wang, W.; Yang, L.; He, D. A conceptual model for the coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China with individual reaction and governmental action. Int. J. Infect. Dis., 2020, 93, 211-216.
[http://dx.doi.org/10.1016/j.ijid.2020.02.058] [PMID: 32145465]
[4]
Tindale, L.C.; Stockdale, J.E.; Coombe, M.; Garlock, E.S.; Lau, W.Y.V.; Saraswat, M.; Zhang, L.; Chen, D.; Wallinga, J.; Colijn, C. Evidence for transmission of COVID-19 prior to symptom onset. eLife, 2020, 9, 9.
[http://dx.doi.org/10.7554/eLife.57149] [PMID: 32568070]
[5]
Velavan, T.P.; Meyer, C.G. The COVID-19 epidemic. Trop. Med. Int. Health, 2020, 25(3), 278-280.
[http://dx.doi.org/10.1111/tmi.13383] [PMID: 32052514]
[6]
Contini, C; Di Nuzzo, M; Barp, N The novel zoonotic COVID-19 pandemic: An expected global health concern J. Infect. Dev. Ctries., 2020, 14(3), 254-64.
[7]
Chu, D.K.; Akl, E.A.; Duda, S.; Solo, K.; Yaacoub, S.; Schünemann, H.J. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet Lond. Engl., 2020, 395, 1973-1987.
[8]
Khan, S; Siddique, R; Shereen, MA Emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2: biology and therapeutic options. J. Clin. Microbiol., 2020, 58(5), e00187.
[9]
Willcox, M.D.; Walsh, K.; Nichols, J.J.; Morgan, P.B.; Jones, L.W. The ocular surface, coronaviruses and COVID-19. Clin. Exp. Optom., 2020, 103(4), 418-424.
[http://dx.doi.org/10.1111/cxo.13088] [PMID: 32406140]
[10]
Lai, T.H.T.; Tang, E.W.H.; Chau, S.K.Y.; Fung, K.S.C.; Li, K.K.W. Stepping up infection control measures in ophthalmology during the novel coronavirus outbreak: an experience from Hong Kong. Graefes Arch. Clin. Exp. Ophthalmol., 2020, 258(5), 1049-1055.
[http://dx.doi.org/10.1007/s00417-020-04641-8] [PMID: 32124000]
[11]
Lu, C.W; Liu, X.F; Jia, Z.F 2019-nCoV transmission through the ocular surface must not be ignored. Lancet Lond. Engl., 2019, 395(10224), 39.
[12]
Liu, L; Sun, Y; Pan, X; Shen, W; Liu, Z; Liu, Y. Expression of SARS coronavirus S protein functional receptor - Angiotensin-converting enzyme 2 in human cornea and conjunctiva 2004, 22, 561-4.
[13]
Palasca, O; Santos, A; Stolte, C; Gorodkin, J; Jensen, L.J. TISSUES 2.0: an integrative web resource on mammalian tissue expression. Database. J. Biol. Databases Curation, 2018, 2018, bay003.
[14]
Hamming, I.; Timens, W.; Bulthuis, M.L.C.; Lely, A.T.; Navis, G.; van Goor, H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J. Pathol., 2004, 203(2), 631-637.
[http://dx.doi.org/10.1002/path.1570] [PMID: 15141377]
[15]
Aiello, F.; Gallo Afflitto, G.; Mancino, R.; Li, J.O.; Cesareo, M.; Giannini, C.; Nucci, C. Coronavirus disease 2019 (SARS-CoV-2) and colonization of ocular tissues and secretions: a systematic review. Eye (Lond.), 2020, 34(7), 1206-1211.
[http://dx.doi.org/10.1038/s41433-020-0926-9] [PMID: 32424327]
[16]
Precaution and prevention of coronavirus disease 2019 (COVID-19) Infection in the Eye. 2019. Available from: https://pubmed.ncbi.nlm.nih.gov/32332516/
[17]
Emparan, J.P.O.; Sardi-Correa, C.; López-Ulloa, J.A.; Viteri-Soria, J.; Penniecook, J.A.; Jimenez-Román, J.; Lansingh, V.C. COVID-19 and the eye: how much do we really know? A best evidence review. Arq. Bras. Oftalmol., 2020, 83(3), 250-261.
[PMID: 32490972]
[18]
Xie, H.T.; Jiang, S.Y.; Xu, K.K.; Liu, X.; Xu, B.; Wang, L.; Zhang, M.C. SARS-CoV-2 in the ocular surface of COVID-19 patients. Eye Vis. (Lond.), 2020, 7, 23.
[http://dx.doi.org/10.1186/s40662-020-00189-0] [PMID: 32355863]
[19]
Karimi, S.; Arabi, A.; Shahraki, T.; Safi, S. Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019. Eye (Lond.), 2020, 34(7), 1220-1223.
[http://dx.doi.org/10.1038/s41433-020-0965-2] [PMID: 32424329]
[20]
The infection evidence of SARS-COV-2 in ocular surface: a single-center cross-sectional study. MedRxiv. Available from: https://www.medrxiv.org/content/10.1101/2020.02.26.20027938v1
[21]
Belser, J.A.; Zeng, H.; Katz, J.M.; Tumpey, T.M. Ocular tropism of influenza A viruses: identification of H7 subtype-specific host responses in human respiratory and ocular cells. J. Virol., 2011, 85(19), 10117-10125.
[http://dx.doi.org/10.1128/JVI.05101-11] [PMID: 21775456]

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