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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Development and Challenges of the Discovery of HER2 Inhibitors

Author(s): Zhi-Gang Sun*, Liang-Hui Zhao, Zhi-Na Li and Hai-Liang Zhu*

Volume 20 , Issue 20 , 2020

Page: [2123 - 2134] Pages: 12

DOI: 10.2174/1389557520666200729162118

Price: $65


The treatment of cancer has always been a major problem in the world. Some cancers cannot be treated with surgery, but only with cancer drugs. Among many cancer drugs, small molecule inhibitors play an irreplaceable role. HER2 is one of the HER families, and the development of HER2 inhibitors has made a huge contribution to the treatment of cancer. Some HER2 inhibitors are already on the market, and some HER2 inhibitors are undergoing clinical research. The design, synthesis and development of new HER2 inhibitors targeting different targets are also ongoing, and some are even under clinical research. The HER2 inhibitors that are on the market have developed resistance, which brings great challenges to the HER2 inhibitor development in the future. This article reviews the development and challenges of the discovery of HER2 inhibitors.

Keywords: Cancer, HER2, challenges, inhibitors, drug resistance, discovery.

Graphical Abstract
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