Current Trends on Hemopoietic Stem Cells

Title:Current Trends on Hemopoietic Stem Cells

Volume: 16 Issue: 2

Author(s): Chinwe Okeke*, Ufele Silas, Chinedu Okeke and Chiedozie Chikwendu

Affiliation:

• Medical Laboratory Science Department, Faculty of Health Science and Tech. University of Nigeria, Nsukka,Nigeria

Keywords: Stem cells, haemopoiesis, transplantation, blood, haemopoietic, differentiation.

Abstract: Advances in single-cell technology and genetic mouse models have resulted in the identification of new types of hemopoietic stem cells (HSC), resulting in baffling observations, suggesting a reconsideration of the long-held notion that all hematopoietic cells in the adult are derived from HSCs. The existence of long-lived HSC-independent hematopoiesis has led to the conclusion that despite the single hierarchical differentiation route that generates functional blood types, other differentiation routes exist in-vivo. Heterogeneity in the HSC population and the evolving knowledge around HSC has translated to it’s improved application as a therapeutic tool for various blood disorders. The reprogramming of non-hematopoietic somatic and mature blood cells to pluripotency with their subsequent differentiation into hematopoietic stem cells/progenitor cells and the introduction of new generation sequencing holds the potential for the resolution of ambiguities involved in HSC bone marrow transplantation. There is a change in the paradigm for HSC transplantation donor selection. Donor choice favors haploidentical HCT than cord blood. This review provides a general overview of the current events around hemopoietic stem cells, with emphasis on the rising trend of HSC transplantation, especially haploidentical stem cell transplantation.

Cite this article as:

Okeke Chinwe *, Silas Ufele , Okeke Chinedu and Chikwendu Chiedozie , Current Trends on Hemopoietic Stem Cells, Current Stem Cell Research & Therapy 2021; 16 (2) . https://dx.doi.org/10.2174/1574888X15999200729162021