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Current Nanoscience


ISSN (Print): 1573-4137
ISSN (Online): 1875-6786

General Research Article

Surface Modification of Electrospun Polyethylenimine/Polyvinyl Alcohol Nanofibers Immobilized with Silver Nanoparticles for Potential Antibacterial Applications

Author(s): Yunchao Xiao, Hui Ma, Xu Fang, Yunpeng Huang, Pengchao Liu* and Xiangyang Shi*

Volume 17 , Issue 2 , 2021

Published on: 28 July, 2020

Page: [279 - 286] Pages: 8

DOI: 10.2174/1573413716999200728154652


Objective: In order to investigate the potential biomedical applications of silver nanoparticle (Ag NP)-immobilized electrospun nanofibers with different surface functionalities.

Methods: Silver nanoparticles were immobilized within water-stable electrospun polyethylenimine (PEI)/polyvinyl alcohol (PVA) nanofibers by an in-situ reduction method after complexing Ag+

Results: In vitro antibacterial activity tests show that Ag NP-containing nanofibrous mats have high antibacterial activity and are capable of inhibiting the growth of both S. aureus and E. coli bacteria. Cell viability assay data show that the Ag NP-containing nanofibers are cytocompatible, and those treated by hydroxylation and acetylation display better cytocompatibility than those treated by carboxylation and the pristine non-modified fibers to promote cell adhesion and proliferation.

Conclusion: Therefore, the hydroxylated or acetylated Ag NP-containing PEI/PVA nanofibers have a great potential for wound dressing, biological protection and tissue engineering applications.

Keywords: Ag nanoparticles, electrospun PEI/PVA nanofibers, different surface functionalities, cytocompatibility, biomedical applications, antibacterial activity.

Graphical Abstract

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