Background: The incidence of thyroid cancer is increasing rapidly and there is an urgent need to explore novel therapeutic targets for thyroid cancer. MiR-140 has been reported to affect the progression of various cancers, which makes it possible to play a role in thyroid cancer. This study aimed to investigate the expression and role of miR-140 in thyroid cancer.
Methods: The expression of miR-140 was investigated by reverse transcription-quantitative polymerase chain reaction (qRT-PCR) in thyroid cancer tissues and cell lines. The prognostic value of miR- 140 in thyroid cancer was evaluated by Kaplan-Meier survival and Cox regression. Moreover, the effects of miR-140 on cell proliferation, migration, and invasion of thyroid cancer were investigated by CCK-8 and Transwell assay.
Results: MiR-140 was downregulated in thyroid cancer tissues and cells, which correlated with TNM stage and lymph node metastasis of patients. Patients with low miR-140 expression had a shorter survival time compared with that in patients with high miR-140 expression. Furthermore, miR-140 acts as an independent factor for the prognosis of thyroid cancer. Overexpression of miR-140 inhibited cell proliferation, migration, and invasion of thyroid cancer.
Conclusion: MiR-140 can serve as a potential prognostic factor for patients with thyroid cancer and suppress the progression of thyroid cancer, which provides new insight for the therapeutic target for thyroid cancer.
[http://dx.doi.org/10.1002/ijc.29210] [PMID: 25220842]
[http://dx.doi.org/10.4149/endo_2014_04_173] [PMID: 25512190]
[http://dx.doi.org/10.1080/21691401.2018.1564320] [PMID: 30849921]
[http://dx.doi.org/10.3892/ijo.2017.3960] [PMID: 28393181]
[http://dx.doi.org/10.1186/s12864-016-2869-x] [PMID: 27502506]
[http://dx.doi.org/10.1038/s41598-019-56018-5] [PMID: 31873114]
[http://dx.doi.org/10.1016/j.ejphar.2019.03.034] [PMID: 30980798]
[http://dx.doi.org/10.18632/aging.102140] [PMID: 31402791]