Neurodegenerative diseases represent one of the most important public health problems and concerns, as they are a growing cause of mortality and morbidity worldwide, particularly in the elderly. However, natural products have a significant function in the avoidance of disease by boosting health in humans as well as animals. These natural products have been scientifically acknowledged to have a range of biological characteristics like antioxidant, and anti-inflammatory actions. Both In vitro and in vivo studies have more recognized the convenience of natural products in different preclinical models of neurodegenerative disorders. Moreover, most NPs comprise phytoconstituents, including polyphenolic antioxidants; originate in herbs, fruits, nuts, vegetables, as well as, also in marine with freshwater flora. These phytoconstituents might actively repress neuro-degeneration and recover memory as like cognitive actions of the brain. Moreover, they are well recognized to participate in an essential position in the prevention of like treatment of different neurodegenerative diseases, like Alzheimer’s disease, Parkinson’s disease, epilepsy, and additional neuronal disorders. However, the large-scale neuro-pharmacological actions of natural products have been familiar owing to the consequence of also the inhibition of inflammatory processes, or the up-regulation of various cell endurance proteins or a mixture of together. Owing to the shortage of human studies on neuroprotective belongings of natural products, this review highlights a variety of documented actions of natural products in vitro and in vivo preclinical models and their possible neuro-protection applications by the accessible awareness in writing.