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Current Diabetes Reviews

Editor-in-Chief

ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Research Article

A Comparative Assessment of Metabolic Syndrome and its Association with Vitamin D and Other Risk Factors in Type 2 Diabetes Mellitus Patients

Author(s): Ammar A. Jairoun, Moyad J. Shahwan* and Mohammed H. Khattab

Volume 17 , Issue 2 , 2021

Published on: 16 July, 2020

Article ID: e311221183812 Pages: 10

DOI: 10.2174/1573399816666200716193115

Price: $65

Abstract

Objectives: To determine the overall prevalence of metabolic syndrome using the World Health Organization (WHO); National Cholesterol Education Program (NCEP), and the International Diabetes Federation (IDF) guidelines and to study its association with vitamin D and other biochemical parameters in patients with type 2 Diabetes mellitus, as well as to identify the set of biochemical parameters that jointly influence the metabolic syndrome using different diagnostic criteria.

Methods: A cross-sectional study was carried out at a private health care center in -a total of 291 diabetic patients. Socio-demographic, clinical, and laboratory data were obtained from the medical records of patients. Statistical analysis was carried out using the Statistical Package for the Social Sciences (SPSS, version 23).

Results: A total number of 291 patients with T2DM were included in this study. The overall prevalence of metabolic syndrome among the study subjects was 48.1%, 87.3%, 64.9% using the WHO, IDF, and NCEP-ATPIII criteria, respectively. The highest prevalence was reported following IDF diagnostic criteria. Sex, triglyceride, and fasting blood sugar were associated factors of metabolic syndrome by all the three diagnostic criteria of metabolic syndrome.

Conclusion: The study revealed a high prevalence rate of metabolic syndrome among type 2 diabetic patients, which was highest at 87.3% according to IDF and lowest was observed according to the WHO criteria i.e, 48.1%. A significant variance in the prevalence of metabolic syndrome was reported between WHO, IDF, and NCEP criteria.

Keywords: Type 2 diabetes, metabolic syndrome, glycemic control, WHO, IDF, NCEP.

[1]
Shahwan MJ, Khattab MH, Jairoun AA. Association of serum calcium level with waist circumference and other biochemical health-care predictors among patients with type 2 diabetes. J Pharm Bioallied Sci 2019; 11(3): 292-8.
[http://dx.doi.org/10.4103/jpbs.JPBS_137_19] [PMID: 31555037]
[2]
World Health Organization. Obesity and Overweight Factsheet from the WHO http://www.thehealthwell.info/node/82914
[3]
West B, Luke A, Durazo-Arvizu RA, Cao G, Shoham D, Kramer H. Metabolic syndrome and self-reported history of kidney stones: the National Health and Nutrition Examination Survey (NHANES III) 1988-1994. Am J Kidney Dis 2008; 51(5): 741-7.
[http://dx.doi.org/10.1053/j.ajkd.2007.12.030] [PMID: 18436084]
[4]
Shahwan M, Jairoun AA, Khattab MH. Association of Serum Calcium Level with Body Mass Index among Type 2 Diabetes Patients in Palestine Obesity Medicine 2019.
[6]
World Health Organization. Global Status Report on Noncommunicable Diseases 2014.http://www.who.int/nmh/publications/ncd-status-report-2014/en/
[7]
International Diabetes Federation. Diabetes Atlas. 8th ed. 2017.
[8]
Ali D, Abduelkarem AR, Shahwan M. Evaluation of factors associated with inadequate glycemic control and some other health care indicators among patients with type 2 diabetes in Ramallah. Res J Pharm Biol Chem Sci 2013; 4(3): 445-51.
[9]
American Diabetes Association (ADA). Standards of medical care in diabetes. Diabetes Care 2016; 39: S1-2.
[10]
Grundy SM, Cleeman JI, Daniels SR, et al. American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation 2005; 112(17): 2735-52.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.105.169404] [PMID: 16157765]
[11]
Stern MP, Williams K, González-Villalpando C, Hunt KJ, Haffner SM. Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease? Diabetes Care 2004; 27(11): 2676-81.
[http://dx.doi.org/10.2337/diacare.27.11.2676] [PMID: 15505004]
[12]
Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37(12): 1595-607.
[http://dx.doi.org/10.2337/diab.37.12.1595] [PMID: 3056758]
[13]
Zimmet PZ, Alberti KG, Shaw JE. Mainstreaming the metabolic syndrome: a definitive definition. Med J Aust 2005; 183(4): 175-6.
[http://dx.doi.org/10.5694/j.1326-5377.2005.tb06987.x] [PMID: 16097912]
[14]
Shahwan MJ, Khattab AH, Khattab MH, Jairoun AA. Association between abnormal serum hepatic enzymes, lipid levels and glycemic control in patients with type 2 diabetes mellitus. Obesity Medicine 2019.e16100137
[http://dx.doi.org/10.1016/j.obmed.2019.100137]
[15]
Chen LY, Qiao QH, Zhang SC, Chen YH, Chao GQ, Fang LZ. Metabolic syndrome and gallstone disease. World J Gastroenterol 2012; 18(31): 4215-20.
[http://dx.doi.org/10.3748/wjg.v18.i31.4215] [PMID: 22919256]
[16]
Lim SS, Davies MJ, Norman RJ, Moran LJ. Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update 2012; 18(6): 618-37.
[http://dx.doi.org/10.1093/humupd/dms030] [PMID: 22767467]
[17]
Dunstan DW, Zimmet PZ, Welborn TA, et al. The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care 2002; 25(5): 829-34.
[http://dx.doi.org/10.2337/diacare.25.5.829] [PMID: 11978676]
[18]
Tong PC, Kong AP, So WY, et al. The usefulness of the International Diabetes Federation and the National Cholesterol Education Program’s Adult Treatment Panel III definitions of the metabolic syndrome in predicting coronary heart disease in subjects with type 2 diabetes. Diabetes Care 2007; 30(5): 1206-11.
[http://dx.doi.org/10.2337/dc06-1484] [PMID: 17259472]
[19]
Wieder-Huszla S, Jurczak A, Szkup M, et al. Relationships between Vitamin D3 and Metabolic Syndrome. Int J Environ Res Public Health 2019; 16(2): 175.
[http://dx.doi.org/10.3390/ijerph16020175] [PMID: 30634516]
[20]
Pacholczyk M, Ferenc T, Kowalski J. Zespół metaboliczny. Część II: patogeneza zespołu metabolicznego i jego powikłań The metabolic syndrome. Part II: Its mechanisms of development and its complications. Postepy Hig Med Dosw 2008; 62: 543-58. [online]
[21]
Parker J, Hashmi O, Dutton D, et al. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas 2010; 65(3): 225-36.
[http://dx.doi.org/10.1016/j.maturitas.2009.12.013] [PMID: 20031348]
[22]
Tamer G, Mesci B, Tamer I, Kilic D, Arik S. Is vitamin D deficiency an independent risk factor for obesity and abdominal obesity in women? Endokrynol Pol 2012; 63(3): 196-201.
[PMID: 22744625]
[23]
Shahwan MJ, Ajlouni K. Prevalence and Risk Factors of Vitamin D Deficiency Among Type 2 Diabetics and Non Diabetics Female Patients Attending the National Center for Diabetes Endocrinology and Genetics in Jordan 2008.
[24]
Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72(3): 690-3.
[http://dx.doi.org/10.1093/ajcn/72.3.690] [PMID: 10966885]
[25]
Cheng S, Massaro JM, Fox CS, et al. Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study. Diabetes 2010; 59(1): 242-8.
[http://dx.doi.org/10.2337/db09-1011] [PMID: 19833894]
[26]
Herath HMM, Weerasinghe NP, Weerarathna TP, Amarathunga A. A Comparison of the Prevalence of the Metabolic Syndrome among Sri Lankan Patients with Type 2 Diabetes Mellitus Using WHO, NCEP-ATP III, and IDF Definitions. Int J Chronic Dis 2018.20187813537
[http://dx.doi.org/10.1155/2018/7813537] [PMID: 30175110]
[27]
Yadav D, Mahajan S, Subramanian SK, Bisen PS, Chung CH, Prasad GB. Prevalence of metabolic syndrome in type 2 diabetes mellitus using NCEP-ATPIII, IDF and WHO definition and its agreement in Gwalior Chambal region of Central India. Glob J Health Sci 2013; 5(6): 142-55.
[http://dx.doi.org/10.5539/gjhs.v5n6p142] [PMID: 24171882]
[28]
Lone S, Lone K, Khan S, Pampori RA. Assessment of metabolic syndrome in Kashmiri population with type 2 diabetes employing the standard criteria’s given by WHO, NCEPATP III and IDF. J Epidemiol Glob Health 2017; 7(4): 235-9.
[http://dx.doi.org/10.1016/j.jegh.2017.07.004] [PMID: 29110863]
[29]
Ford ES, Giles WH. A comparison of the prevalence of the metabolic syndrome using two proposed definitions. Diabetes Care 2003; 26(3): 575-81.
[http://dx.doi.org/10.2337/diacare.26.3.575] [PMID: 12610004]
[30]
Osuji CU, Nzerem BA, Dioka CE, Onwubuya EI. Metabolic syndrome in newly diagnosed type 2 diabetes mellitus using NCEP-ATP III, the Nnewi experience. Niger J Clin Pract 2012; 15(4): 475-80.
[http://dx.doi.org/10.4103/1119-3077.104530] [PMID: 23238201]
[31]
Pokharel DR, Khadka D, Sigdel M, et al. Prevalence of metabolic syndrome in Nepalese type 2 diabetic patients according to WHO, NCEP ATP III, IDF and Harmonized criteria. J Diabetes Metab Disord 2014; 13(1): 104.
[http://dx.doi.org/10.1186/s40200-014-0104-3] [PMID: 25469328]
[32]
Onesi SO, Ignatius UE. Metabolic syndrome: Performance of five different diagnostic criterias. Indian J Endocrinol Metab 2014; 18(4): 496-501.
[http://dx.doi.org/10.4103/2230-8210.137494] [PMID: 25143905]
[33]
World Medical Association. Declaration of Helsinki Ethical principles for medical research involving human subjects 2009; 14(1): 233-8.
[34]
Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15(7): 539-53.
[http://dx.doi.org/10.1002/(SICI)10969136(199807)15:7<539:AID-DIA668>3.0.CO;2-S] [PMID: 9686693]
[35]
International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome 2005.http://www.idf.org/webdata/docs/Met_Syn_definition
[36]
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Expert Panel on Detection E. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001; 285(19): 2486-97.
[http://dx.doi.org/10.1001/jama.285.19.2486] [PMID: 11368702]
[37]
Birarra MK, Gelayee DA. Metabolic syndrome among type 2 diabetic patients in Ethiopia: a cross-sectional study. BMC Cardiovasc Disord 2018; 18(1): 149.
[http://dx.doi.org/10.1186/s12872-018-0880-7] [PMID: 30016936]
[38]
Katsiki N, Anagnostis P, Kotsa K, Goulis DG, Mikhailidis DP. Obesity, metabolic syndrome and the risk of microvascular complications in patients with diabetes mellitus. Curr Pharm Des 2019; 25(18): 2051-9.
[http://dx.doi.org/10.2174/1381612825666190708192134] [PMID: 31298151]
[39]
Gahlan D, Rajput R, Singh V. Metabolic syndrome in north Indian type 2 diabetes mellitus patients: A comparison of four different diagnostic criteria of metabolic syndrome. Diabetes Metab Syndr 2019; 13(1): 356-62.
[http://dx.doi.org/10.1016/j.dsx.2018.10.011] [PMID: 30641725]
[40]
Kengne AP, Limen SN, Sobngwi E, Djouogo CF, Nouedoui C. Metabolic syndrome in type 2 diabetes: comparative prevalence according to two sets of diagnostic criteria in sub-Saharan Africans. Diabetol Metab Syndr 2012; 4(1): 22.
[http://dx.doi.org/10.1186/1758-5996-4-22] [PMID: 22650602]
[41]
Randhawa FA, Mustafa S, Khan DM, Hamid S. Effect of Vitamin D supplementation on reduction in levels of HbA1 in patients recently diagnosed with type 2 Diabetes Mellitus having asymptomatic Vitamin D deficiency. Pak J Med Sci 2017; 33(4): 881-5.
[http://dx.doi.org/10.12669/pjms.334.12288] [PMID: 29067058]
[42]
Karhapää P, Pihlajamäki J, Pörsti I, et al. Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias. J Intern Med 2010; 268(6): 604-10.
[http://dx.doi.org/10.1111/j.1365-2796.2010.02279.x] [PMID: 20831628]
[43]
Williams DM, Fraser A, Sayers A, et al. Associations of 25-hydroxyvitamin D2 and D3 with cardiovascular risk factors in childhood: cross-sectional findings from the Avon Longitudinal Study of Parents and Children. J Clin Endocrinol Metab 2012; 97(5): 1563-71.
[http://dx.doi.org/10.1210/jc.2011-2335] [PMID: 22344194]
[44]
Grimes DS, Hindle E, Dyer T. Sunlight, cholesterol and coronary heart disease. QJM 1996; 89(8): 579-89.
[http://dx.doi.org/10.1093/qjmed/89.8.579] [PMID: 8935479]

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