Login Register Cart 0
Generic placeholder image

Reviews on Recent Clinical Trials

Editor-in-Chief

ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
General Review Article

Honey Against Radiation-induced Oral Mucositis in Head and Neck Cancer Patients. An Umbrella Review of Systematic Reviews and Meta- Analyses of the Literature

Author(s): Areti Gkantaifi*, Filippo Alongi, Emmanouil Vardas, Francesco Cuccia, Jiannis Hajiioannou, Efthymios Kyrodimos, Christos Christopoulos, Davide Mauri, Nikolaos Charalampakis, Nikolaos Trogkanis, Nikolaos Tsoukalas, George Iliadis and Maria Tolia

Volume 15, Issue 4, 2020

Page: [360 - 369] Pages: 10

DOI: 10.2174/1574887115666200709140405

Price: $65

Abstract

Backround: Oral mucositis (OM) consists of a major side effect of radiotherapy (RT) in head and neck (H-N) cancer patients and natural honey is gaining more and more scientific interest due to its beneficial effects in tissue repair.

Objective: The aim of this review is to better clarify the preventive/therapeutic role of honey in the management of OM in patients with H-N cancer undergoing RT with or without chemotherapy (CT).

Methods: We used the PubMed database to retrieve journal articles and the inclusion criteria were only reviews and meta-analyses that illustrated the effective use of honey for either the prevention or treatment of OM in H-N cancer patients receiving either RT alone or in combination with CT.

Results: Our search resulted in 92 citations, of which 12 eventually fulfilled the inclusion criteria of our study. Decreased incidence and severity of OM, extended time of occurrence of mucositis, less weight loss and less treatment interruptions were occasionally documented with conventional honey use in the included reviews and meta-analyses. In contrast to conventional honey, manuka honey proved to be weak in improving OM management in the small number of included reviews in our search.

Conclusion: Conventional honey might constitute a highly promising natural product against OM attracting much scientific interest due to its easy accessibility and low financial cost. Hence, the lack of studies with high evidence requires further advanced research to enhance the existing knowledge about the potential value of honey in radiation-induced OM in H-N cancer patients.

Keywords: Oral mucositis, honey, radiotherapy, head and neck cancer, prevention, treatment.

« Previous Next »
Graphical Abstract

[1]
He M. Interventions for preventing oral mucositis in patients with cancer receiving treatment. Clin Nurse Spec 2011; 25(6): 284-5.
[http://dx.doi.org/10.1097/NUR.0b013e318233e951] [PMID: 22016015]
[2]
Maurer J, Hipp M, Schäfer C, Kölbl O. Dysphagia. Impact on quality of life after radio(chemo)therapy of head and neck cancer. Strahlenther Onkol 2011; 187(11): 744-9.
[http://dx.doi.org/10.1007/s00066-011-2275-x] [PMID: 22037655]
[3]
Erdem O, Güngörmüş Z. The effect of royal jelly on oral mucositis in patients undergoing radiotherapy and chemotherapy. Holist Nurs Pract 2014; 28(4): 242-6.
[http://dx.doi.org/10.1097/HNP.0000000000000033] [PMID: 24919094]
[4]
Lalla RV, Bowen J, Barasch A, et al. Mucositis guidelines leadership group of the multinational association of supportive care in cancer and international society of oral oncology (MASCC/ISOO). Cancer 2014; 120(10): 1453-61.
[http://dx.doi.org/10.1002/cncr.28592] [PMID: 24615748]
[5]
Ariyawardana A, Cheng KKF, Kandwal A, et al. Mucositis study group of the multinational association of supportive care in cancer/international society for oral oncology (MASCC/ISOO). Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer 2019; 27(10): 3985-95.
[http://dx.doi.org/10.1007/s00520-019-04888-w] [PMID: 31286230]
[6]
Nicolatou-Galitis O, Sarri T, Bowen J, et al. Mucositis study group of the multinational association of supportive care in cancer/international society of oral oncology (MASCC/ISOO). Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients. Support Care Cancer 2013; 21(11): 3179-89.
[http://dx.doi.org/10.1007/s00520-013-1847-y] [PMID: 23702538]
[7]
Saunders DP, Epstein JB, Elad S, et al. Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients. Support Care Cancer 2013; 21(11): 3191-207.
[http://dx.doi.org/10.1007/s00520-013-1871-y] [PMID: 23832272]
[8]
Jayakrishnan R, Chang K, Ugurluer G, Miller RC, Sio TT. Doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancers. Oncol Rev 2015; 9(1): 290.
[http://dx.doi.org/10.4081/oncol.2015.290] [PMID: 26779314]
[9]
Sarvizadeh M, Hemati S, Meidani M, Ashouri M, Roayaei M, Shahsanai A. Morphine mouthwash for the management of oral mucositis in patients with head and neck cancer. Adv Biomed Res 2015; 4: 44.
[http://dx.doi.org/10.4103/2277-9175.151254] [PMID: 25789270]
[10]
Dutta K, Garg R. Morphine mouthwash in oral mucositis: A mini review. Palliat Med Hosp Care Open J 2016; 2(2): 26-9.
[http://dx.doi.org/10.17140/PMHCOJ-2-115]
[11]
Moslemi D, Babaee N, Damavandi M, et al. Oral zinc sulphate and prevention of radiation-induced oropharyngeal mucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial. Int JRadiat Res 2014; 12(3): 235-41.
[12]
de Menêses AG, Normando AGC, Porto de Toledo I, Reis PED, Guerra ENS. Effects of oral supplementation in the management of oral mucositis in cancer patients: A meta-analysis of randomized clinical trials. J Oral Pathol Med 2020; 49(2): 117-25.
[http://dx.doi.org/10.1111/jop.12901] [PMID: 31172573]
[13]
Abo Enin HA, El Nabarawy NA, Elmonem RA. Treatment of radiation-induced oral mucositis using a novel accepted taste of prolonged release mucoadhesive bi-medicated double-layer buccal films. AAPS PharmSciTech 2017; 18(2): 563-75.
[http://dx.doi.org/10.1208/s12249-016-0533-z] [PMID: 27138037]
[14]
Hu W, Chen L, Wang C, et al. Standardized nursing and therapeutic effect of oxycontin on oral mucosal pain in nasopharyngeal carcinoma patients. J Cancer Res Ther 2018; 14(7): 1594-9.
[http://dx.doi.org/10.4103/jcrt.JCRT_551_18] [PMID: 30589045]
[15]
Satheeshkumar PS, Chamba MS, Balan A, Sreelatha KT, Bhatathiri VN, Bose T. Effectiveness of triclosan in the management of radiation-induced oral mucositis: A randomized clinical trial. J Cancer Res Ther 2010; 6(4): 466-72.
[http://dx.doi.org/10.4103/0973-1482.77109] [PMID: 21358082]
[16]
Rao NG, Han G, Greene JN, et al. Effect of prophylactic fluconazole on oral mucositis and candidiasis during radiation therapy for head-and-neck cancer. Pract Radiat Oncol 2013; 3(3): 229-33.
[http://dx.doi.org/10.1016/j.prro.2012.05.008] [PMID: 24674369]
[17]
Bensadoun RJ, Franquin JC, Ciais G, et al. Low-energy He/Ne laser in the prevention of radiation-induced mucositis. A multicenter phase III randomized study in patients with head and neck cancer. Support Care Cancer 1999; 7(4): 244-52.
[http://dx.doi.org/10.1007/s005200050256] [PMID: 10423050]
[18]
Lopez-Vaquero D, Gutierrez-Bayard L, Rodriguez-Ruiz JA, Saldaña-Valderas M, Infante-Cossio P. Double-blind randomized study of oral glutamine on the management of radio/chemotherapy-induced mucositis and dermatitis in head and neck cancer. Mol Clin Oncol 2017; 6(6): 931-6.
[http://dx.doi.org/10.3892/mco.2017.1238] [PMID: 28588793]
[19]
MügeAkmansu Sevilayİren, GülGüntürkün.. The Effect of using oral glutamine on the side effect of mucositis in patients with head and neck cancer who are receiving chemoradiotherapy: Retrospective evaluation with clinical and immunological parameters. Turk J Oncol 2018; 33(3): 115-21.
[20]
Gu J, Zhu S, Li X, Wu H, Li Y, Hua F. Effect of amifostine in head and neck cancer patients treated with radiotherapy: A systematic review and meta-analysis based on randomized controlled trials. PLoS One 2014; 9(5): , e95968.
[http://dx.doi.org/10.1371/journal.pone.0095968] [PMID: 24788761]
[21]
Chang H, Yi W, Wang X, et al. Effectiveness and safety of different amifostine regimens: Preliminary results of a phase II multicenter randomized controlled trial. Chin J Cancer Res 2018; 30(3): 307-14.
[http://dx.doi.org/10.21147/j.issn.1000-9604.2018.03.03] [PMID: 30046225]
[22]
Kartin PT, Tasci S, Soyuer S, Elmali F. Effect of an oral mucositis protocol on quality of life of patients with head and neck cancer treated with radiation therapy. Clin J Oncol Nurs 2014; 18(6): E118-25.
[http://dx.doi.org/10.1188/14.CJON.E118-E125] [PMID: 25427714]
[23]
Kubota K, Kobayashi W, Sakaki H, et al. Professional oral health care reduces oral mucositis pain in patients treated by superselective intra-arterial chemotherapy concurrent with radiotherapy for oral cancer. Support Care Cancer 2015; 23(11): 3323-9.
[http://dx.doi.org/10.1007/s00520-015-2774-x] [PMID: 25987235]
[24]
Kong M, Hwang DS, Yoon SW, Kim J. The effect of clove-based herbal mouthwash on radiation-induced oral mucositis in patients with head and neck cancer: A single-blind randomized preliminary study. OncoTargets Ther 2016; 9: 4533-8.
[http://dx.doi.org/10.2147/OTT.S108769] [PMID: 27524909]
[25]
Babaee N, Moslemi D, Khalilpour M, et al. Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: A randomized controlled clinical study. Daru 2013; 21(1): 18.
[http://dx.doi.org/10.1186/2008-2231-21-18] [PMID: 23497687]
[26]
Patil K, Guledgud MV, Kulkarni PK, Keshari D, Tayal S. Use of curcumin mouthrinse in radio-chemotherapy induced oral mucositis patients: A Pilot Study. J Clin Diagn Res 2015; 9(8): ZC59-62.
[http://dx.doi.org/10.7860/JCDR/2015/13034.6345] [PMID: 26436049]
[27]
Normando AGC, de Menêses AG, de Toledo IP, et al. Effects of turmeric and curcumin on oral mucositis: A systematic review. Phytother Res 2019; 33(5): 1318-29.
[http://dx.doi.org/10.1002/ptr.6326] [PMID: 30838707]
[28]
Kuo CC, Wang RH, Wang HH, Li CH. Meta-analysis of randomized controlled trials of the efficacy of propolis mouthwash in cancer therapy-induced oral mucositis. Support Care Cancer 2018; 26(12): 4001-9.
[http://dx.doi.org/10.1007/s00520-018-4344-5] [PMID: 30022350]
[29]
Kiprian D, Jarzabski A, Kawecki A. Evaluation of efficacy of Caphosol in prevention and alleviation of acute side effects in patients treated with radiotherapy for head and neck cancers. Contemp Oncol (Pozn) 2016; 20(5): 389-93.
[http://dx.doi.org/10.5114/wo.2016.64600] [PMID: 28373821]
[30]
Das D, Agarwal SK, Chandola HM. Protective effect of Yashtimadhu (Glycyrrhiza glabra) against side effects of radiation/chemotherapy in head and neck malignancies. Ayu 2011; 32(2): 196-9.
[http://dx.doi.org/10.4103/0974-8520.92579] [PMID: 22408302]
[31]
Najafi S, Koujan SE, Manifar S, Kharazifard MJ, Kidi S, Hajheidary S. Preventive effect of glycyrrhiza glabra extract on oral mucositis in patients under head and neck radiotherapy: A randomized clinical trial. J Dent (Tehran) 2017; 14(5): 267-74.
[PMID: 29296112]
[32]
Wei J, Wu J, Meng L, et al. Effects of early nutritional intervention on oral mucositis in patients with radiotherapy for head and neck cancer. QJM 2020; 113(1): 37-42.
[http://dx.doi.org/10.1093/qjmed/hcz222] [PMID: 31432089]
[33]
Chaitanya NC, Muthukrishnan A, Babu DBG, et al. Role of Vitamin E and Vitamin A in oral mucositis induced by cancer chemo/radiotherapy- A meta-analysis. J Clin Diagn Res 2017; 11(5): ZE06-9.
[http://dx.doi.org/10.7860/JCDR/2017/26845.9905] [PMID: 28658926]
[34]
Sun H, Zhu X, Li D, Cheng T. Effects of a compound vitamin B mixture in combination with GeneTime® on radiation-induced oral mucositis. J Int Med Res 2019; 47(5): 2126-34.
[http://dx.doi.org/10.1177/0300060519831171] [PMID: 30938568]
[35]
Al-Waili NS, Saloom KY. Effects of topical honey on post-operative wound infections due to gram positive and gram negative bacteria following caesarean sections and hysterectomies. Eur J Med Res 1999; 4(3): 126-30.
[PMID: 10085281]
[36]
Maiti PK, Ray A, Mitra TN, Jana U, Bhattacharya J, Ganguly S. The effect of honey on mucositis induced by chemoradiation in head and neck cancer. J Indian Med Assoc 2012; 110(7): 453-6.
[PMID: 23520669]
[37]
Charalambous A, Charalambous M, Raftopoulos V, et al. The effectiveness of thymus honey on radiation induced mucositis and xerostomia for head and neck cancer patients: Preliminary findings of a RCT. Support Care Cancer 2013; 21(Suppl. 1): S125.
[38]
Francis M, Williams S. Effectiveness of indian turmeric powder with honey as complementary therapy on oral mucositis : A nursing perspective among cancer patients in mysore. Nurs J India 2014; 105(6): 258-60.
[PMID: 26182820]
[39]
Bahramnezhad F, Dehghan Nayeri N, Bassampour SS, Khajeh M, Asgari P. Honey and radiation-induced stomatitis in patients With head and neck cancer. Iran Red Crescent Med J 2015; 17(10): e19256.
[http://dx.doi.org/10.5812/ircmj.19256] [PMID: 26568850]
[40]
Alvi ZA, Mahmood A, Rasool S, et al. Role of honey in prevention of radiation induced mucositis in head and neck cancer. Pak Armed Forces Med J 2013; 63: 379-83.
[http://dx.doi.org/10.1016/S0167-8140(15)34726-5]
[41]
Amanat A, Ahmed A, Kazmi A, Aziz B. The effect of honey on radiation-induced oral mucositis in head and neck cancer patients. Indian J Palliat Care 2017; 23(3): 317-20.
[http://dx.doi.org/10.4103/IJPC.IJPC_146_16] [PMID: 28827938]
[42]
Bansal A, Ghoshal S, Yadav BK, et al. Exploring the role of “glycerine plus honey” in delaying chemoradiation induced oral mucositis in head and neck cancers. Int J Cancer TherOncol 2017; 5: 1-7.
[43]
Rao S, Hegde SK, Rao P, et al. Honey mitigates radiation-induced oral mucositis in head and neck cancer patients without affecting the tumor response. Foods 2017; 6(9): , E77.
[http://dx.doi.org/10.3390/foods6090077] [PMID: 28878156]
[44]
Molan PC. Honey as a topical antibacterial agent for the treatment of effected wounds. Worldwide wounds available at: http://www.worldwidewounds.com/2001/november/molan/honey-as-topical-agent.html[11/2001]. 2001.
[45]
Hyslop PA, Hinshaw DB, Scraufstatter IU, Cochrane CG, Kunz S, Vosbeck K. Hydrogen peroxide as a potent bacteriostatic antibiotic: implications for host defense. Free Radic Biol Med 1995; 19(1): 31-7.
[http://dx.doi.org/10.1016/0891-5849(95)00005-I] [PMID: 7635356]
[46]
White JW. Composition of honey. Honey A comprehensive survey. London: Heinemann Edition 1975; pp. 157-206.
[47]
Bardy J, Slevin NJ, Mais KL, Molassiotis A. A systematic review of honey uses and its potential value within oncology care. J Clin Nurs 2008; 17(19): 2604-23.
[http://dx.doi.org/10.1111/j.1365-2702.2008.02304.x] [PMID: 18808626]
[48]
Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials 1996; 17(1): 1-12.
[http://dx.doi.org/10.1016/0197-2456(95)00134-4] [PMID: 8721797]
[49]
Sela MO, Shapira L, Grizim I, et al. Effects of honey consumption on enamel microhardness in normal versus xerostomic patients. J Oral Rehabil 1998; 25(8): 630-4.
[http://dx.doi.org/10.1046/j.1365-2842.1998.00274.x] [PMID: 9781867]
[50]
Sela M, Maroz D, Gedalia I. Streptococcus mutans in saliva of normal subjects and neck and head irradiated cancer subjects after consumption of honey. J Oral Rehabil 2000; 27(3): 269-70.
[http://dx.doi.org/10.1046/j.1365-2842.2000.00504.x] [PMID: 10784339]
[51]
Biswal BM, Zakaria A, Ahmad NM. Topical application of honey in the management of radiation mucositis: A preliminary study. Support Care Cancer 2003; 11(4): 242-8.
[http://dx.doi.org/10.1007/s00520-003-0443-y] [PMID: 12673463]
[52]
Worthington HV, Clarkson JE, Bryan G, et al. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev 2011; (4): CD000978..
[http://dx.doi.org/10.1002/14651858.CD000978.pub5] [PMID: 21491378]
[53]
Motallebnejad M, Akram S, Moghadamnia A, Moulana Z, Omidi S. The effect of topical application of pure honey on radiation-induced mucositis: A randomized clinical trial. J Contemp Dent Pract 2008; 9(3): 40-7.
[http://dx.doi.org/10.5005/jcdp-9-3-40] [PMID: 18335118]
[54]
Rashad UM, Al-Gezawy SM, El-Gezawy E, Azzaz AN. Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer. J Laryngol Otol 2009; 123(2): 223-8.
[http://dx.doi.org/10.1017/S0022215108002478] [PMID: 18485252]
[55]
Song JJ, Twumasi-Ankrah P, Salcido R. Systematic review and meta-analysis on the use of honey to protect from the effects of radiation-induced oral mucositis. Adv Skin Wound Care 2012; 25(1): 23-8.
[http://dx.doi.org/10.1097/01.ASW.0000410687.14363.a3] [PMID: 22218067]
[56]
Chiba M, Idobata K, Kobayashi N, Sato Y, Muramatsu Y. [Use of honey to ease the pain of stomatitis during radiotherapy]. Kangogaku Zasshi 1985; 49(2): 171-6.
[PMID: 3845150]
[57]
Khanal B, Baliga M, Uppal N. Effect of topical honey on limitation of radiation-induced oral mucositis: An intervention study. Int J Oral Maxillofac Surg 2010; 39(12): 1181-5.
[http://dx.doi.org/10.1016/j.ijom.2010.05.014] [PMID: 20832243]
[58]
Yarom N, Ariyawardana A, Hovan A, et al. Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). Systematic review of natural agents for the management of oral mucositis in cancer patients. Support Care Cancer 2013; 21(11): 3209-21.
[http://dx.doi.org/10.1007/s00520-013-1869-5] [PMID: 23764678]
[59]
Somerfield M, Padberg J, Pfister D, et al. ASCO clinical practice guidelines: Process, progress, pitfalls, and prospects. Class PapCurr Comments 2000; 4(4): 881-6.
[60]
Charalambous M, Raftopoulos V, Lambrinou E, et al. The effectiveness of honey for the management of radiotherapy-induced oral mucositis in the head and neck cancer patients: A systematic review of clinical trials. Eur J Int Med 2013; 5(3): 217-25.
[http://dx.doi.org/10.1016/j.eujim.2013.01.003]
[61]
Bardy J, Molassiotis A, Ryder WD, et al. A double-blind, placebo-controlled, randomised trial of active manuka honey and standard oral care for radiation-induced oral mucositis. Br J Oral Maxillofac Surg 2012; 50(3): 221-6.
[http://dx.doi.org/10.1016/j.bjoms.2011.03.005] [PMID: 21636188]
[62]
Cho HK, Jeong YM, Lee HS, Lee YJ, Hwang SH. Effects of honey on oral mucositis in patients with head and neck cancer: A meta-analysis. Laryngoscope 2015; 125(9): 2085-92.
[http://dx.doi.org/10.1002/lary.25233] [PMID: 25778825]
[63]
Maddocks-Jennings W, Wilkinson JM, Cavanagh HM, Shillington D. Evaluating the effects of the essential oils Leptospermum scoparium (manuka) and Kunzea ericoides (kanuka) on radiotherapy induced mucositis: A randomized, placebo controlled feasibility study. Eur J Oncol Nurs 2009; 13(2): 87-93.
[http://dx.doi.org/10.1016/j.ejon.2009.01.002] [PMID: 19297246]
[64]
Hawley P, Hovan A, McGahan CE, Saunders D. A randomized placebo-controlled trial of manuka honey for radiation-induced oral mucositis. Support Care Cancer 2014; 22(3): 751-61.
[http://dx.doi.org/10.1007/s00520-013-2031-0] [PMID: 24221577]
[65]
Co JL, Mejia MB, Que JC, Dizon JM. Effectiveness of honey on radiation-induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta-analysis and systematic review of literature. Head Neck 2016; 38(7): 1119-28.
[http://dx.doi.org/10.1002/hed.24431] [PMID: 27028991]
[66]
Parsons E, Begley A, Herst P. Manuka honey mouthwash does not affect oral mucositis in head and neck cancer patients in New Zealand. J Radiother Pract 2012; 11(4): 249-56.
[http://dx.doi.org/10.1017/S1460396911000410]
[67]
Jayachandran S, Balaji N. Evaluating the effectiveness of topical application of natural honey and benzydamine hydrochloride in the management of radiation mucositis. Indian J Palliat Care 2012; 18(3): 190-5.
[http://dx.doi.org/10.4103/0973-1075.105689] [PMID: 23439942]
[68]
Xu JL, Xia R, Sun ZH, et al. Effects of honey use on the management of radio/chemotherapy-induced mucositis: a meta-analysis of randomized controlled trials. Int J Oral Maxillofac Surg 2016; 45(12): 1618-25.
[http://dx.doi.org/10.1016/j.ijom.2016.04.023] [PMID: 27600797]
[69]
Nagi R, Patil DJ, Rakesh N, Jain S, Sahu S. Natural agents in the management of oral mucositis in cancer patients-systematic review. J Oral Biol Craniofac Res 2018; 8(3): 245-54.
[http://dx.doi.org/10.1016/j.jobcr.2017.12.003] [PMID: 30191118]
[70]
Abdulrhman M, Elbarbary NS, Ahmed Amin D, Saeid Ebrahim R. Honey and a mixture of honey, beeswax, and olive oil-propolis extract in treatment of chemotherapy-induced oral mucositis: A randomized controlled pilot study. Pediatr Hematol Oncol 2012; 29(3): 285-92.
[http://dx.doi.org/10.3109/08880018.2012.669026] [PMID: 22475306]
[71]
Raeessi MA, Raeessi N, Panahi Y, et al. “Coffee plus honey” versus “topical steroid” in the treatment of chemotherapy-induced oral mucositis: A randomised controlled trial. BMC Complement Altern Med 2014; 14: 293.
[http://dx.doi.org/10.1186/1472-6882-14-293] [PMID: 25106776]
[72]
Thomsen M, Vitetta L. Adjunctive treatments for the prevention of chemotherapy- and radiotherapy-induced mucositis. Integr Cancer Ther 2018; 17(4): 1027-47.
[http://dx.doi.org/10.1177/1534735418794885] [PMID: 30136590]
[73]
Jayalekshmi JL, Lakshmi R, Mukerji A. Honey on oral mucositis: A Randomized controlled trial. Gulf J Oncolog 2016; 1(20): 30-7.
[PMID: 27050177]
[74]
Samdariya S, Lewis S, Kauser H, Ahmed I, Kumar D. A randomized controlled trial evaluating the role of honey in reducing pain due to radiation induced mucositis in head and neck cancer patients. Indian J Palliat Care 2015; 21(3): 268-73.
[http://dx.doi.org/10.4103/0973-1075.164892] [PMID: 26600693]
[75]
Fogh SE, Deshmukh S, Berk LB, et al. A randomized phase 2 trial of prophylactic manuka honey for the reduction of chemoradiation therapy-induced esophagitis during thetreatment of lung cancer: Results of NRG Oncology RTOG 1012. Int J Radiat Oncol Biol Phys 2017; 97(4): 786-96.
[http://dx.doi.org/10.1016/j.ijrobp.2016.11.022] [PMID: 28244415]
[76]
Farneti A, Sanguineti G, Marucci L, et al. Double-blind randomized phase 3 study comparing a mixture of natural ingredients versus placebo in the prevention of acute mucositis during chemoradiation therapy for head and neck cancer. Int J Radiat Oncol Biol Phys 2015; 93(3)(Suppl. 1): S212-3.
[http://dx.doi.org/10.1016/j.ijrobp.2015.07.511]
[77]
Münstedt K, Momm F, Hübner J. Honey in the management of side effects of radiotherapy- or radio/chemotherapy-induced oral mucositis. A systematic review. Complement Ther Clin Pract 2019; 34: 145-52.
[http://dx.doi.org/10.1016/j.ctcp.2018.11.016] [PMID: 30712719]
[78]
Charalambous M, Raftopoulos V, Paikousis L, et al. The effect of the use of thyme honey in minimizing radiation - induced oral mucositis in head and neck cancer patients: A randomized controlled trial. Eur J Oncol Nurs 2018; 34: 89-97.
[http://dx.doi.org/10.1016/j.ejon.2018.04.003] [PMID: 29784145]
[79]
Yang C, Gong G, Jin E, et al. Topical application of honey in the management of chemo/radiotherapy-induced oral mucositis: A systematic review and network meta-analysis. Int J Nurs Stud 2019; 89: 80-7.
[http://dx.doi.org/10.1016/j.ijnurstu.2018.08.007] [PMID: 30352321]
[80]
Higgins JP, Altman DG, Gøtzsche PC, et al. Cochrane Bias Methods Group; Cochrane Statistical Methods Group. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 2011; 343: d5928.
[http://dx.doi.org/10.1136/bmj.d5928] [PMID: 22008217]
[81]
Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010; 25(9): 603-5.
[http://dx.doi.org/10.1007/s10654-010-9491-z] [PMID: 20652370]
[82]
Mazzola R, Fiorentino A, Ricchetti F, Gregucci F, Corradini S, Alongi F. An update on radiation therapy in head and neck cancers. Expert Rev Anticancer Ther 2018; 18(4): 359-64.
[http://dx.doi.org/10.1080/14737140.2018.1446832] [PMID: 29485913]
[83]
Mazzola R, Ricchetti F, Fersino S, et al. Predictors of mucositis in oropharyngeal and oral cavity cancer in patients treated with volumetric modulated radiation treatment: A dose-volume analysis. Head Neck 2016; 38(Suppl. 1): E815-9.
[http://dx.doi.org/10.1002/hed.24106] [PMID: 25920015]

Rights & Permissions Print Cite
Article Metrics
32
© 2024 Bentham Science Publishers | Privacy Policy