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Current Reviews in Clinical and Experimental Pharmacology


ISSN (Print): 2772-4328
ISSN (Online): 2772-4336

Research Article

The Influence of Selank on the Level of Cytokines Under the Conditions of “Social” Stress

Author(s): Yasenyavskaya A. Leonidovna*, Samotrueva M. Aleksandrovna, Tsibizova A. Aleksandrovna, Bashkina O. Aleksandrovna, Myasoedov N. Fedorovich and Andreeva L. Aleksandrovna

Volume 16, Issue 2, 2021

Published on: 04 July, 2020

Page: [162 - 167] Pages: 6

DOI: 10.2174/1574884715666200704152810

Price: $65


Background: It was previously thought that inflammation and an immune response were the only factors capable of causing IL-1β, IL-6 and other cytokine`s production. In recent years data have appeared that stressful effects can also occupy an important place, enhancing production of IL- 1β, IL-6 and other cytokines; the result will be a change in the functional activity of a particular cell element, for example immunocompetent cells with subsequent development of inflammation, or a change in the functional activity of neurons. This experiment is aimed at studying the effect of the Selank glyprolin neuropeptide drug on the level of cytokines in animals under conditions of “social” stress, the results of which indicate the presence of stress-protective activity.

Methods: White nonlinear rats were used as experimental animals. A model of confrontations between males was chosen to create a “social” stress. The animals were in pairs in a cage which were separated by a septum preventing physical contact but having openings that provide sensory contact. Each day, the septum was removed for 10 minutes leading in an overwhelming majority to agonistic collisions (confrontations). Laboratory animals were divided into 3 groups: a group of intact males, a group of animals that were subjected to stress (sensory contact) for 20 days and a group that received intraperitoneally Selank at a dose of 100 mcg/kg/day under conditions of 20-day stress. The level of cytokines under study was determined by enzyme-linked immunosorbent assay.

Results: As a result of the work performed to determine the concentration of pro-inflammatory and anti- inflammatory cytokines, it was found that in the serum of animals exposed to stress, there was a statistically significant increase in the level of IL-1β, IL-6 and TGF-β1 in individuals with both types of behavior. It should be noted that, under the conditions of this stressful impact, there was a tendency to decrease the concentration of IL-4 and increase the level of TNF-α but these indicators were not statistically significant. Evaluation of the effect of Semax on the level of the cytokines in a stress-induced state showed that this neuropeptide causes a decrease in the concentration of IL-1β and IL-6, restoration of the level of IL-4, as well as suppression of the production of TGF-β1 and TNF-α in these conditions.

Conclusion: This peptide is able to reduce the concentration of IL-1β, IL-6 and TNF-α, as well as TGF-β1, practically reaching control values, when studying the effect of Selank on the level of cytokines under conditions of " social" stress. There is the need for a detailed study of the role of cytokines in the development of stress-induced changes in order to find optimal correction tools.

Keywords: Pathophysiology, immunocompetent, hematopoietic cells, interleukins, neurotransmitters, hormones.

Graphical Abstract
Abramov VV, Abramova TY. Interleukin-1 in the cytokine network: Fundamental and applied aspects. Succ Mod Biol 2007; 127(6): 570-9.
Cadle CE, Zoladz PR. Stress time-dependently influences the acquisition and retrieval of unrelated information by producing a memory of its own. Front Psychol 2015; 6(6): 910.
[] [PMID: 26175712]
Dinarello CA. IL-1: Discoveries, controversies and future directions. Eur J Immunol 2010; 40(3): 599-606.
[] [PMID: 20201008]
Glaser R, Kiecolt-Glaser JK. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 2005; 5(3): 243-51.
[] [PMID: 15738954]
Kasian A, Kolomin T, Andreeva L, et al. Peptide selank enhances the effect of diazepam in reducing anxiety in unpredictable chronic mild stress conditions in rats. Behav Neurol 2017; 2017: 5091027.
[] [PMID: 28280289]
Kudryavtseva NN. Serotonergic control of aggressive behavior: New approaches - new interpretations. Zh Vyssh Nerv Deiat Im I P Pavlova 2015; 65(5): 546-63.
[PMID: 26859999]
Kudryavtseva NN. The sensory contact model for the study of aggressive and submissive behaviors in male mice. Aggress Behav 1991; 17(5): 285-91.
Ménard C, Pfau ML, Hodes GE, Russo SJ. Immune and neuroendocrine mechanisms of stress vulnerability and resilience. Neuropsychopharmacology 2017; 42(1): 62-80.
[] [PMID: 27291462]
Romero-Martínez Á, Moya-Albiol L. 2017; Stress-induced endocrine and immune dysfunctions in caregivers of people with eating disorders Int J Environ Res Publ Health 2017; 14(12): 1560.
Rose-John S. Interleukin-6 Family (2018). Cytokines CSH Perspect Biol 2018; 10(2): 1560.
Samotrueva MA, Sergalieva MU, Yasenyavskaya AL, et al. Information stress: Causes, experimental models, effects on the body. Astrakh Med J 2015; 10(4): 25-30.
Samotrueva MA, Yasenyavskaya AL, Tsibizova AA, et al. Neuroimmunoendocrinology: Current understanding of molecular mechanisms. Immunology 2017; 38(1): 49-59.
Sarapultsev PA, Sarapultsev AP. Stress and the immune system. Cytokines and Inflammation 2014; 13(4): 5-10.
Tanaka T, Narazaki M, Masuda K, Kishimoto T. Regulation of IL-6 in Immunity and Diseases. Adv Exp Med Biol 2016; 941: 79-88.
[] [PMID: 27734409]
Tyurenkov IN, Samotrueva MA, Tsibizova AA, Yasenyavskaya AL. Phenotropil as a modulator of the level of cytokines in experimental immunopathology. Exp Clin Pharm 2015; 78(12): 15-7.
[PMID: 27051922]
Volkova A, Shadrina M, Kolomin T, et al. Selank administration affects the expression of some genes involved in GABaergic neurotransmission. Front Pharmacol 2016; 7(7): 31.
[] [PMID: 26924987]

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