Background: To date, there is no consensus on the best combination of direct-acting antivirals to treat hepatitis C virus in kidney transplant recipients.
Objective: This study aims to analyze the efficacy of a combination of sofosbuvir and ledipasvir regimen for the treatment of hepatitis C virus infected kidney transplant patients.
Methods: A cross-sectional study was conducted in a nephrology clinic and the Nephrology Center in Basrah Teaching Hospital from June 2015 to June 2018. Ledifos (90 mg Ledipasvir and 400 mg Sofosbuvir fixed-dose) was given as a single daily dose to all the participants for 12 weeks. Response for therapy was tested by a follow up hepatitis C virus load at the end of 12 weeks and after 24 weeks. The sustained virological response was defined as a negative viral load of hepatitis C virus (aviremia) at the end of therapy. This study was done according to the Helsinki Congress.
Results: A total of 60 (16 females) patients with renal transplantation and hepatitis C virus infection were included. The mean age was 40±6.2 years. A sustained virological response was observed in all of the patients who received Ledifos after 12 and 24 weeks of therapy for all genotypes (1a, 1b and 4); p= 0.0001. Genotype 1a was more prevalent among males, in about 34 (56.6%) of the patients; p= 0.0001, and it was the most common genotype that tested negative serologically, 11 (18.3%).
Conclusion: Ledifos therapy is an effective and safe option for the treatment of hepatitis C virus infection in the post-renal transplant setting.
Keywords: Hepatitis C virus, kidney transplant, direct antiviral drug, genotype, ledipasvir, sofosbuvir, sustained virological response.
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