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Anti-Infective Agents


ISSN (Print): 2211-3525
ISSN (Online): 2211-3533

Research Article

Efficacy of Direct-Acting Antiviral Combination Therapy in the Treatment of Hepatitis C Virus Among Kidney Transplant Patients

Author(s): Mohammed Al Atbee, Saad Shaheen Al-Taher and Majid Alabbood*

Volume 19, Issue 2, 2021

Published on: 03 July, 2020

Page: [169 - 173] Pages: 5

DOI: 10.2174/2211352518999200703114432

Price: $65


Background: To date, there is no consensus on the best combination of direct-acting antivirals to treat hepatitis C virus in kidney transplant recipients.

Objective: This study aims to analyze the efficacy of a combination of sofosbuvir and ledipasvir regimen for the treatment of hepatitis C virus infected kidney transplant patients.

Methods: A cross-sectional study was conducted in a nephrology clinic and the Nephrology Center in Basrah Teaching Hospital from June 2015 to June 2018. Ledifos (90 mg Ledipasvir and 400 mg Sofosbuvir fixed-dose) was given as a single daily dose to all the participants for 12 weeks. Response for therapy was tested by a follow up hepatitis C virus load at the end of 12 weeks and after 24 weeks. The sustained virological response was defined as a negative viral load of hepatitis C virus (aviremia) at the end of therapy. This study was done according to the Helsinki Congress.

Results: A total of 60 (16 females) patients with renal transplantation and hepatitis C virus infection were included. The mean age was 40±6.2 years. A sustained virological response was observed in all of the patients who received Ledifos after 12 and 24 weeks of therapy for all genotypes (1a, 1b and 4); p= 0.0001. Genotype 1a was more prevalent among males, in about 34 (56.6%) of the patients; p= 0.0001, and it was the most common genotype that tested negative serologically, 11 (18.3%).

Conclusion: Ledifos therapy is an effective and safe option for the treatment of hepatitis C virus infection in the post-renal transplant setting.

Keywords: Hepatitis C virus, kidney transplant, direct antiviral drug, genotype, ledipasvir, sofosbuvir, sustained virological response.

Graphical Abstract
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