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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Mini-Review Article

Traceable Peptidic Ligands that Target Ghrelin Receptors

Author(s): Mengjie Liu, John Wade* and Mohammed Akhter Hossain*

Volume 21, Issue 10, 2020

Page: [955 - 964] Pages: 10

DOI: 10.2174/1389203721666200702131457

Price: $65

Abstract

Ghrelin is a 28-amino acid octanoylated peptide hormone that is implicated in many physiological and pathophysiological processes. Specific visualization of ghrelin and its cognate receptor using traceable ligands is crucial in elucidating the localization, functions, and expression pattern of the peptide’s signaling pathway. Here 12 representative radio- and fluorescently-labeled peptide-based ligands are reviewed for in vitro and in vivo imaging studies. In particular, the focus is on their structural features, pharmacological properties, and applications in further biochemical research.

Keywords: ghrelin, ghrelin receptor, peptide, radiolabeling, fluorescence, ligand.

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Graphical Abstract

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