Login Register Cart 0
Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Novel Nanocarriers for the Treatment of Wound Healing

Author(s): Venkateshwaran Krishnaswami, Nikhishaa Sree Raju, Shanmugarathinam Alagarsamy and Ruckmani Kandasamy*

Volume 26, Issue 36, 2020

Page: [4591 - 4600] Pages: 10

DOI: 10.2174/1381612826666200701203432

Price: $65

Abstract

The sequence of biochemical and cellular responses restoring the integrity of the subcutaneous tissue of the skin is termed as wound healing. Inflammatory cytokine suppression and inflammatory transduction cascades are the major targets for wound healing. Formulations for wound healing should promote neovascularization and angiogenic pathways by increasing the expression of vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor. Medication used for wound healing promotes antiinflammatory associated with anti-bacterial action. In order to boost the effectiveness of current medical treatments, the cutting-edge nanotechnology offers many novel therapies. This review summarized and discussed wound healing, types of wounds, natural materials used for wound healing, metallic nanoparticles and current nano drug delivery systems used for wound healing with special emphasis on the angiogenesis role in the healing of wounds.

Keywords: Wound, healing, angiogenesis, nano-drug, treatment, nanotechnology.

« Previous Next »
[1]
Dekoninck S, Blanpain C. Stem cell dynamics, migration and plasticity during wound healing. Nat Cell Biol 2019; 21(1): 18-24.
[http://dx.doi.org/10.1038/s41556-018-0237-6 ] [PMID: 30602767]
[2]
Eming SA. Introduction to wound healing and tissue repair.Atlas of Ulcers in Systemic Sclerosis.Cham: Springer 2019; 39-41.
[http://dx.doi.org/10.1007/978-3-319-98477-3_5]
[3]
Johnson ZI, Mahoney C, Heo J, Frankel E, Julian DR, Yates CC. The role of chemokines in fibrotic dermal remodeling and wound healing. Fibrosis in disease molecular and translational medicine. Cham: Humana Press 2019; 3-24.
[http://dx.doi.org/10.1007/978-3-319-98143-7_1]
[4]
Sabale P, Bhimani B, Prajapati C, Sabale V. An overview of medicinal plants as wound healers. J Appl Pharm Sci 2012; 2(11): 143-50.
[5]
Raina R, Prawez S, Verma PK, Pankaj NK. Medicinal plants and their role in wound healing. Vet Scan 2008; 3: 1-7.
[6]
Davis RH, Donato JJ, Hartman GM, Haas RC. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. J Am Podiatr Med Assoc 1994; 84(2): 77-81.
[http://dx.doi.org/10.7547/87507315-84-2-77 ] [PMID: 8169808]
[7]
Oryan A, Alemzadeh E, Mohammadi AA, Moshiri A. Healing potential of injectable Aloe vera hydrogel loaded by adipose-derived stem cell in skin tissue-engineering in a rat burn wound model. Cell Tissue Res 2019; 377(2): 215-27.
[http://dx.doi.org/10.1007/s00441-019-03015-9 ] [PMID: 30923912]
[8]
Gadien LA, Karim AK, Suliman E, Ahmaed DT, Ghada M. Formulation, characterization and stability study of Azadirachta indica (neem) fruits extract. World J Pharm Pharm Sci 2018; 8: 209-21.
[9]
Udupa SL, Shetty S, Udupa AL, Somayaji SN. Effect of Ocimum sanctum Linn. on normal and dexamethasone suppressed wound healing. Indian J Exp Biol 2006; 44(1): 49-54.
[PMID: 16430091]
[10]
Gupta VK, Kumar A. Assessment of burn wound healing property of ocimum sanctum by grading of epithelial regeneration in rabbits. Int J Med Sci Clin Invent 2018; 5: 3865-7.
[11]
Alam G, Singh MP, Singh A. Wound healing potential of some medicinal plants. Int J Pharm Sci Rev Res 2011; 9: 136-45.
[12]
Chin CY, Ng PY, Ng SF. Moringa oleifera standardised aqueous leaf extract-loaded hydrocolloid film dressing: in vivo dermal safety and wound healing evaluation in STZ/HFD diabetic rat model. Drug Deliv Transl Res 2019; 9(2): 453-68.
[http://dx.doi.org/10.1007/s13346-018-0510-z ] [PMID: 29560587]
[13]
Arunachalam KD, Subhashini S, Annamalai SK. Wound healing and antigenotoxic activities of Aegle marmelos with relation to its antioxidant properties. J Pharm Res 2012; 5: 1492-502.
[14]
Perumal A, Krishna S, Madhusree M. GC-MS analysis, antioxidant and antibacterial activities of ethanol extract of leaves of Aegle marmelos (L.). J Drug Deliv Ther 2018; 8: 247-55.
[http://dx.doi.org/10.22270/jddt.v8i4.1781]
[15]
Shirwaikar A, Ghosh S, Padma GM. Effect of Gmelina arborea Roxb. leaves on wound healing in rats. J Nat Rem 2003; 3: 45-8.
[16]
Prakashbabu BC, Vijay D, George S, et al. Wound healing and anti-inflammatory activity of methanolic extract of Gmelina arborea and Hemigraphis colorata in rats. Int J Curr Microbiol Appl Sci 2017; 6: 3116-22.
[http://dx.doi.org/10.20546/ijcmas.2017.608.373]
[17]
Gupta M, Agrawal U, Vyas SP. Nanocarrier-based topical drug delivery for the treatment of skin diseases. Expert Opin Drug Deliv 2012; 9(7): 783-804.
[http://dx.doi.org/10.1517/17425247.2012.686490 ] [PMID: 22559240]
[18]
Oyarzun-Ampuero F, Vidal A, Concha M, Morales J, Orellana S, Moreno-Villoslada I. Nanoparticles for the treatment of wounds. Curr Pharm Des 2015; 21(29): 4329-41.
[http://dx.doi.org/10.2174/1381612821666150901104601 ] [PMID: 26323420]
[19]
Chaloupka K, Malam Y, Seifalian AM. Nanosilver as a new generation of nanoproduct in biomedical applications. Trends Biotechnol 2010; 28(11): 580-8.
[http://dx.doi.org/10.1016/j.tibtech.2010.07.006 ] [PMID: 20724010]
[20]
Rai M, Yadav A, Gade A. Silver nanoparticles as a new generation of antimicrobials. Biotechnol Adv 2009; 27(1): 76-83.
[http://dx.doi.org/10.1016/j.biotechadv.2008.09.002 ] [PMID: 18854209]
[21]
Ruparelia JP, Chatterjee AK, Duttagupta SP, Mukherji S. Strain specificity in antimicrobial activity of silver and copper nanoparticles. Acta Biomater 2008; 4(3): 707-16.
[http://dx.doi.org/10.1016/j.actbio.2007.11.006 ] [PMID: 18248860]
[22]
Kim JS, Kuk E, Yu KN, et al. Antimicrobial effects of silver nanoparticles. Nanomedicine (Lond) 2007; 3(1): 95-101.
[http://dx.doi.org/10.1016/j.nano.2006.12.001 ] [PMID: 17379174]
[23]
Tian J, Wong KK, Ho CM, et al. Topical delivery of silver nanoparticles promotes wound healing. ChemMedChem 2007; 2(1): 129-36.
[http://dx.doi.org/10.1002/cmdc.200600171 ] [PMID: 17075952]
[24]
Adhya A, Bain J, Ray O, et al. Healing of burn wounds by topical treatment: A randomized controlled comparison between silver sulfadiazine and nano-crystalline silver. J Basic Clin Pharm 2014; 6(1): 29-34.
[http://dx.doi.org/10.4103/0976-0105.145776 ] [PMID: 25538469]
[25]
Ye H, Cheng J, Yu K. In situ reduction of silver nanoparticles by gelatin to obtain porous silver nanoparticle/chitosan composites with enhanced antimicrobial and wound-healing activity. Int J Biol Macromol 2019; 121: 633-42.
[http://dx.doi.org/10.1016/j.ijbiomac.2018.10.056 ] [PMID: 30326224]
[26]
Niska K, Zielinska E, Radomski MW, Inkielewicz-Stepniak I. Metal nanoparticles in dermatology and cosmetology: Interactions with human skin cells. Chem Biol Interact 2018; 295: 38-51.
[http://dx.doi.org/10.1016/j.cbi.2017.06.018 ] [PMID: 28641964]
[27]
Vijayakumar V, Samal SK, Mohanty S, Nayak SK. Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management. Int J Biol Macromol 2019; 122: 137-48.
[http://dx.doi.org/10.1016/j.ijbiomac.2018.10.120 ] [PMID: 30342131]
[28]
Leu JG, Chen SA, Chen HM, et al. The effects of gold nanoparticles in wound healing with antioxidant epigallocatechin gallate and α-lipoic acid. Nanomedicine (Lond) 2012; 8(5): 767-75.
[http://dx.doi.org/10.1016/j.nano.2011.08.013 ] [PMID: 21906577]
[29]
Mahmoud NN, Hikmat S, Abu Ghith D, et al. Gold nanoparticles loaded into polymeric hydrogel for wound healing in rats: Effect of nanoparticles’ shape and surface modification. Int J Pharm 2019; 565: 174-86.
[http://dx.doi.org/10.1016/j.ijpharm.2019.04.079 ] [PMID: 31075436]
[30]
Sen CK, Khanna S, Venojarvi M, et al. Copper-induced vascular endothelial growth factor expression and wound healing. Am J Physiol Heart Circ Physiol 2002; 282(5): H1821-7.
[http://dx.doi.org/10.1152/ajpheart.01015.2001 ] [PMID: 11959648]
[31]
Borkow G, Gabbay J, Dardik R, et al. Molecular mechanisms of enhanced wound healing by copper oxide-impregnated dressings. Wound Repair Regen 2010; 18(2): 266-75.
[http://dx.doi.org/10.1111/j.1524-475X.2010.00573.x ] [PMID: 20409151]
[32]
Singh M, Manikandan S, Kumaraguru AK. Nanoparticles: a new technology with wide applications. Res J Nanosci Nanotechnol 2011; 1: 1.
[http://dx.doi.org/10.3923/rjnn.2011.1.11]
[33]
Tiwari M, Narayanan K, Thakar MB, Jagani HV, Venkata Rao J. Biosynthesis and wound healing activity of copper nanoparticles. IET Nanobiotechnol 2014; 8(4): 230-7.
[http://dx.doi.org/10.1049/iet-nbt.2013.0052 ] [PMID: 25429502]
[34]
Gopal A, Kant V, Gopalakrishnan A, Tandan SK, Kumar D. Chitosan-based copper nanocomposite accelerates healing in excision wound model in rats. Eur J Pharmacol 2014; 731: 8-19.
[http://dx.doi.org/10.1016/j.ejphar.2014.02.033 ] [PMID: 24632085]
[35]
Sivaranjani V, Philominathan P. Synthesize of Titanium dioxide nanoparticles using Moringa oleifera leaves and evaluation of wound healing activity. Wound Med 2016; 12: 1-5.
[http://dx.doi.org/10.1016/j.wndm.2015.11.002]
[36]
Sankar R, Dhivya R, Shivashangari KS, Ravikumar V. Wound healing activity of Origanum vulgare engineered titanium dioxide nanoparticles in Wistar Albino rats. J Mater Sci Mater Med 2014; 25(7): 1701-8.
[http://dx.doi.org/10.1007/s10856-014-5193-5 ] [PMID: 24682905]
[37]
Khalid A, Ullah H, Ul-Islam M, et al. Bacterial cellulose-TiO 2 nanocomposites promote healing and tissue regeneration in burn mice model. RSC Advances 2017; 7: 47662-8.
[http://dx.doi.org/10.1039/C7RA06699F]
[38]
Kumar PT, Lakshmanan VK, Anilkumar TV, et al. Flexible and microporous chitosan hydrogel/nano ZnO composite bandages for wound dressing: in vitro and in vivo evaluation. ACS Appl Mater Interfaces 2012; 4(5): 2618-29.
[http://dx.doi.org/10.1021/am300292v ] [PMID: 22489770]
[39]
Balaure PC, Holban AM, Grumezescu AM, et al. In vitro and in vivo studies of novel fabricated bioactive dressings based on collagen and zinc oxide 3D scaffolds. Int J Pharm 2019; 557: 199-207.
[http://dx.doi.org/10.1016/j.ijpharm.2018.12.063 ] [PMID: 30597267]
[40]
Yang H, Liu C, Yang D, Zhang H, Xi Z. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J Appl Toxicol 2009; 29(1): 69-78.
[http://dx.doi.org/10.1002/jat.1385 ] [PMID: 18756589]
[41]
Gao Y, Han Y, Cui M, Tey HL, Wang L, Xu C. ZnO nanoparticles as an antimicrobial tissue adhesive for skin wound closure. J Mater Chem B Mater Biol Med 2017; 5(23): 4535-41.
[http://dx.doi.org/10.1039/C7TB00664K ] [PMID: 32263980]
[42]
Augustine R, Dominic EA, Reju I, Kaimal B, Kalarikkal N, Thomas S. Electrospun polycaprolactone membranes incorporated with ZnO nanoparticles as skin substitutes with enhanced fibroblast proliferation and wound healing. RSC Advances 2014; 4: 24777-85.
[http://dx.doi.org/10.1039/c4ra02450h]
[43]
Yadav E, Singh D, Yadav P, Verma A. Ameliorative effect of biofabricated ZnO nanoparticles of Trianthema portulacastrum Linn. on dermal wounds via removal of oxidative stress and inflammation. RSC Advances 2018; 8: 21621-35.
[http://dx.doi.org/10.1039/C8RA03500H]
[44]
Aslan A, Elanthikkal S, Bozkurt A. Chitosan/hollow silica sphere nanocomposites for wound healing application. J Mater Res 2019; 34: 231-9.
[http://dx.doi.org/10.1557/jmr.2018.430]
[45]
Alvarez GS, Hélary C, Mebert AM, Wang X, Coradin T, Desimone MF. Antibiotic-loaded silica nanoparticle-collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention. J Mater Chem B Mater Biol Med 2014; 2(29): 4660-70.
[http://dx.doi.org/10.1039/c4tb00327f ] [PMID: 32262278]
[46]
Öri F, Dietrich R, Ganz C, et al. Silicon-dioxide-polyvinylpyrrolidone as a wound dressing for skin defects in a murine model. J Craniomaxillofac Surg 2017; 45(1): 99-107.
[http://dx.doi.org/10.1016/j.jcms.2016.10.002 ] [PMID: 27986365]
[47]
Arafa MG, El-Kased RF, Elmazar MM. Thermoresponsive gels containing gold nanoparticles as smart antibacterial and wound healing agents. Sci Rep 2018; 8(1): 13674.
[http://dx.doi.org/10.1038/s41598-018-31895-4 ] [PMID: 30209256]
[48]
Lau P, Bidin N, Islam S, et al. Influence of gold nanoparticles on wound healing treatment in rat model: Photobiomodulation therapy. Lasers Surg Med 2017; 49(4): 380-6.
[http://dx.doi.org/10.1002/lsm.22614 ] [PMID: 27859389]
[49]
Rakhshaei R, Namazi H. A potential bioactive wound dressing based on carboxymethyl cellulose/ZnO impregnated MCM-41 nanocomposite hydrogel. Mater Sci Eng C 2017; 73: 456-64.
[http://dx.doi.org/10.1016/j.msec.2016.12.097 ] [PMID: 28183632]
[50]
Guo C, Li M, Qi X, et al. Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic mice. Sci Rep 2016; 6: 29753.
[http://dx.doi.org/10.1038/srep29753 ] [PMID: 27405815]
[51]
Varshosaz J, Taymouri S, Minaiyan M, Rastegarnasab F, Baradaran A. Development and in vitro/in vivo evaluation of HPMC/chitosan gel containing simvastatin loaded self-assembled nanomicelles as a potent wound healing agent. Drug Dev Ind Pharm 2018; 44(2): 276-88.
[http://dx.doi.org/10.1080/03639045.2017.1391832 ] [PMID: 29043860]
[52]
Sugumar S, Ghosh V, Nirmala MJ, Mukherjee A, Chandrasekaran N. Ultrasonic emulsification of eucalyptus oil nanoemulsion: antibacterial activity against Staphylococcus aureus and wound healing activity in Wistar rats. Ultrason Sonochem 2014; 21(3): 1044-9.
[http://dx.doi.org/10.1016/j.ultsonch.2013.10.021 ] [PMID: 24262758]
[53]
Shanmugapriya K, Kim H, Kang HW. A new alternative insight of nanoemulsion conjugated with κ-carrageenan for wound healing study in diabetic mice: In vitro and in vivo evaluation. Eur J Pharm Sci 2019; 133: 236-50.
[http://dx.doi.org/10.1016/j.ejps.2019.04.006 ] [PMID: 30965083]
[54]
Xu H, Yuan XD, Shen BD, et al. Development of poly(N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment. J Biomater Appl 2014; 28(9): 1376-85.
[http://dx.doi.org/10.1177/0885328213509503 ] [PMID: 24163330]
[55]
Liu X, Gan H, Hu C, et al. Silver sulfadiazine nanosuspension-loaded thermosensitive hydrogel as a topical antibacterial agent. Int J Nanomedicine 2018; 14: 289-300.
[http://dx.doi.org/10.2147/IJN.S187918 ] [PMID: 30643407]
[56]
Aguzzi C, Sandri G, Bonferoni C, et al. Solid state characterisation of silver sulfadiazine loaded on montmorillonite/chitosan nanocomposite for wound healing. Colloids Surf B Biointerfaces 2014; 113: 152-7.
[http://dx.doi.org/10.1016/j.colsurfb.2013.08.043 ] [PMID: 24077113]
[57]
Fan Y, Wu W, Lei Y, et al. Edaravone-loaded alginate-based nanocomposite hydrogel accelerated chronic wound healing in diabetic mice. Mar Drugs 2019; 17(5): 285.
[http://dx.doi.org/10.3390/md17050285 ] [PMID: 31083588]
[58]
Miguel SP, Figueira DR, Simões D, et al. Electrospun polymeric nanofibres as wound dressings: A review. Colloids Surf B Biointerfaces 2018; 169: 60-71.
[http://dx.doi.org/10.1016/j.colsurfb.2018.05.011 ] [PMID: 29747031]
[59]
Saha K, Dutta K, Basu A, Adhikari A, Chattopadhyay D, Sarkar P. Controlled delivery of tetracycline hydrochloride intercalated into smectite clay using polyurethane nanofibrous membrane for wound healing application. Nano-Structures & Nano-Objects 2020; 21100418.
[http://dx.doi.org/10.1016/j.nanoso.2019.100418]
[60]
Amini F, Semnani D, Karbasi S, Banitaba SN. A novel bilayer drug-loaded wound dressing of PVDF and PHB/Chitosan nanofibers applicable for post-surgical ulcers. Int J Polym Mater 2019; 68: 772-7.
[http://dx.doi.org/10.1080/00914037.2018.1506982]
[61]
Saghazadeh S, Rinoldi C, Schot M, et al. Drug delivery systems and materials for wound healing applications. Adv Drug Deliv Rev 2018; 127: 138-66.
[http://dx.doi.org/10.1016/j.addr.2018.04.008 ] [PMID: 29626550]
[62]
Fan X, Yang L, Wang T, Sun T, Lu S. pH-responsive cellulose-based dual drug-loaded hydrogel for wound dressing. Eur Polym J 2019; 121109290
[http://dx.doi.org/10.1016/j.eurpolymj.2019.109290]
[63]
Cardoso AM, de Oliveira EG, Coradini K, et al. Chitosan hydrogels containing nanoencapsulated phenytoin for cutaneous use: Skin permeation/penetration and efficacy in wound healing. Mater Sci Eng C 2019; 96: 205-17.
[http://dx.doi.org/10.1016/j.msec.2018.11.013 ] [PMID: 30606527]
[64]
Alibolandi M, Mohammadi M, Taghdisi SM, Abnous K, Ramezani M. Synthesis and preparation of biodegradable hybrid dextran hydrogel incorporated with biodegradable curcumin nanomicelles for full thickness wound healing. Int J Pharm 2017; 532(1): 466-77.
[http://dx.doi.org/10.1016/j.ijpharm.2017.09.042 ] [PMID: 28927842]
[65]
Tahergorabi Z, Khazaei M. A review on angiogenesis and its assays. Iran J Basic Med Sci 2012; 15(6): 1110-26.
[PMID: 23653839]
[66]
Vijayan A. A S, Kumar GSV. PEG grafted chitosan scaffold for dual growth factor delivery for enhanced wound healing. Sci Rep 2019; 9(1): 19165.
[http://dx.doi.org/10.1038/s41598-019-55214-7 ] [PMID: 31844069]
[67]
Wang T, Zheng Y, Shi Y, Zhao L. pH-responsive calcium alginate hydrogel laden with protamine nanoparticles and hyaluronan oligosaccharide promotes diabetic wound healing by enhancing angiogenesis and antibacterial activity. Drug Deliv Transl Res 2019; 9(1): 227-39.
[http://dx.doi.org/10.1007/s13346-018-00609-8 ] [PMID: 30519937]
[68]
Hamdan S, Pastar I, Drakulich S, et al. Nanotechnology-driven therapeutic interventions in wound healing: potential uses and applications. ACS Cent Sci 2017; 3(3): 163-75.
[http://dx.doi.org/10.1021/acscentsci.6b00371 ] [PMID: 28386594]
[69]
Augustine R, Prasad P, Khalaf IMN. Therapeutic angiogenesis: From conventional approaches to recent nanotechnology-based interventions. Mater Sci Eng C 2019; 97: 994-1008.
[http://dx.doi.org/10.1016/j.msec.2019.01.006 ] [PMID: 30678987]
[70]
Khatami M, Varma RS, Zafarnia N, Yaghoobi H, Sarani M, Kumar VG. Applications of green synthesized Ag, ZnO and Ag/ZnO nanoparticles for making clinical antimicrobial wound-healing bandages. Sustain Chem Pharm 2018; 10: 9-15.
[http://dx.doi.org/10.1016/j.scp.2018.08.001]
[71]
Naraginti S, Kumari PL, Das RK, Sivakumar A, Patil SH, Andhalkar VV. Amelioration of excision wounds by topical application of green synthesized, formulated silver and gold nanoparticles in albino Wistar rats. Mater Sci Eng C 2016; 62: 293-300.
[http://dx.doi.org/10.1016/j.msec.2016.01.069 ] [PMID: 26952426 ]

Rights & Permissions Print Cite
Article Metrics
62
4
World Health Day
© 2024 Bentham Science Publishers | Privacy Policy