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Mini-Reviews in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Review Article

Progress in [18F]Fluorination by Using Aryliodonium(III) Compounds and Application for PET Tracer Syntheses

Author(s): Kotaro Kikushima*, Ravi Kumar and Toshifumi Dohi*

Volume 18, Issue 2, 2021

Published on: 29 June, 2020

Page: [173 - 196] Pages: 24

DOI: 10.2174/1570193X17999200629155733

Price: $65

Abstract

[18F]-labeled drugs and radioligands are most frequently used in positron-emission tomography (PET) radiopharmaceuticals for both clinical and preclinical research. Various methods for the introduction of [18F]fluorine into complex molecules through fluorination reactions have been reported. Herein, recent advances in [18F]-fluorination utilizing aryliodonium(III) compounds are highlighted.

Keywords: [18F]fluorine, aryliodonium compound, fluoroarene, late-stage fluorination, PET imaging, radiosynthesis.

Graphical Abstract
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