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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Review Article

Fibroblast Growth Factor: Promising Target for Schizophrenia

Author(s): Ali Talaei, Tahereh Farkhondeh and Fatemeh Forouzanfar*

Volume 21 , Issue 13 , 2020

Page: [1344 - 1353] Pages: 10

DOI: 10.2174/1389450121666200628114843

Price: $65

Abstract

Schizophrenia is one of the most debilitating mental disorders around the world. It is characterized by neuroanatomical or biochemical changes. The role of the fibroblast growth factors (FGFs) system in schizophrenia has received considerable attention in recent years. Various changes in the gene expression and/or level of FGFs have been implicated in the etiology, symptoms and progression of schizophrenia. For example, studies have substantiated an interaction between FGFs and the signaling pathway of dopamine receptors. To understand the role of this system in schizophrenia, the databases of Open Access Journals, Web of Science, PubMed (NLM), LISTA (EBSCO), and Google Scholar with keywords including fibroblast growth factors, dopamine, schizophrenia, psychosis, along with neurotrophic were searched. In conclusion, the FGF family represent molecular candidates as new drug targets and treatment targets for schizophrenia.

Keywords: Fibroblast growth factors, dopamine, schizophrenia, psychosis, neurotrophic, antipsychotic drugs.

Graphical Abstract
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