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Coronaviruses

Editor-in-Chief

ISSN (Print): 2666-7967
ISSN (Online): 2666-7975

Opinion Article

COVID-19: An Opinion of Prevention and Dietary Based Management Hypothesis

Author(s): Ashraf Talaat Youssef*

Volume 2, Issue 2, 2021

Published on: 23 June, 2020

Page: [138 - 141] Pages: 4

DOI: 10.2174/2666796701999200623172916

Abstract

Mentions the pandemic as starting in China, with a subsequent worldwide spread. The viral infection can seriously affect multiple organs, mainly lungs, kidneys, heart, liver, and brain, and may lead to respiratory, renal, cardiac, or hepatic failure. Vascular thrombosis of unexplained mechanism may lead to widespread blood clots in multiple organs and cytokine storms that are a result of overstimulation of the immune system subsequent to lung damage, may lead to sudden decompensation due to hypotension and cause more damage to liver, kidney, brain or lungs. Until now, no drug has proved to be efficient in getting rid of the problem and controlling the pandemic mainly depends on preventive measures. Many measures can be considered to prevent the worldwide spread of the viral transmission. Polyunsaturated long chain fatty acids (PUFAs), medium chain saturated fatty acids (MCSFAs), and their corresponding monoglycerides have high antiviral activities against the enveloped viruses, which reached more than 10,000 -fold reduction in the viral titers in vitro and in vivo after testing for gastric aspirate, and can contribute to the systemic immunity against the enveloped viruses.

Keywords: COVID-19, COVID-19 prevention, COVID-19 management hypothesis, polyunsaturated long chain fatty acid, triglycerides, medium chain saturated fatty acid triglycerides.

[1]
Coronaviridae study group of the international committee on taxonomy of viruses. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 2020; 5: 536-44.
[http://dx.doi.org/doi.org/10.1038/s41564-020-0695-z] [PMID: 32123347]
[2]
Centers for Disease Control and Prevention. Coronavirus disease 2019. (COVID-19): situation summary. Available from: https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/summary.html (Accessed March 18, 2020)
[3]
Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet 2020; 395(10223): 470-3.
[PMID: 31986257]
[4]
Feng Z, Li Q, Zhang Y, et al. Vital surveillances: the epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) — China, 2020. China CDC Weekly 2020; 2(8): 113-22.http://weekly.chinacdc.cn/en/article/id/e53946e2-c6c4-41e9-9a9b-fea8db1a8f51
[5]
Gardner L. Mapping 2019-nCoV. Johns Hopkins University, Center for Systems Science and Engineering (JHU CSSE). Available from: https://systems.jhu.edu/research/public-health/ncov/ (Accessed February 3, 2020)
[6]
Johns Hopkins University, Center for Systems Science and Engineering. Coronavirus COVID-19 global cases (JHU CSSE). Available from: https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6 (Accessed February 18, 2020)
[7]
Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents. J Hosp Infect 2020; 104(3): 246-51.
[http://dx.doi.org/doi.org/10.1016/j.jhin.2020.01.022] [PMID: 32035997.]
[8]
van Doremalen N, Bushmaker T, Morris DH, et al. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med 2020; 382: 1564-7.
[http://dx.doi.org/doi.org/10.1056/NEJMc2004973]
[9]
Hijnen D, Marzano AV, Eyerich K, et al. SARS-CoV-2 transmission from presymptomatic meeting attendee, Germany. Emerg Infect Dis 2020; 26(8): 1.
[http://dx.doi.org/doi.org/10.3201/eid2608.201235]
[10]
She J, Liu L, Liu W. COVID‐19 epidemic: disease characteristics in children. J Med Virol 2020; 92(7): 747-54.
[http://dx.doi.org/10.1002/jmv.25807]
[11]
hormar H, Isaacs CE, Brown HR, Barshatzky MR, Pessolano T. Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrob Agents Chemother 1987; 31(1): 27-31.
[http://dx.doi.org/doi.org/10.1128/aac.31.1.27]
[12]
Isaacs CE, Thormar H, Pessolano T. Membrane-disruptive effect of human milk: inactivation of enveloped viruses. J Infect Dis 1986; 154(6): 966-71.
[http://dx.doi.org/doi.org/10.1093/infdis/154.6.966]
[13]
Isaacs CE, Kashyap S, Heird WC, Thormar H. Antiviral and antibacterial lipids in human milk and infant formula feeds. Arch Dis Child 1990; 65: 861-4.
[http://dx.doi.org/doi.org/10.1136/adc.65.8.861]
[14]
Fischer CL. Antimicrobial activity of host-derived lipids. Antibiotics 2020; 9(2): 75.
[http://dx.doi.org/doi.org/10.3390/antibiotics9020075]
[15]
Yoon BK, Jackman JA, Valle-González ER, Cho NJ. Antibacterial free fatty acids and Monoglycerides: biological activities, experimental testing, and therapeutic applications. Int J Mol Sci 2018; 19(4): 1114.
[http://dx.doi.org/doi.org/10.3390/ijms19041114]
[16]
Thormar H. Lipids and essential oils as antimicrobial agents. Hoboken: John Wiley & Sons 2010.
[17]
Kohn A, Gitelman J, Inbar M. Unsaturated free fatty acids inactivate animal enveloped viruses. Arch Virol 1980; 66(4): 301-7.
[http://dx.doi.org/doi.org/10.1007/BF01320626]
[18]
Merchant AT, Curhan GC, Rimm EB, Willett WC, Fawzi WW. Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pneumonia in US men. Am J Clin Nutr 2005; 82(3): 668-74.
[19]
Hamosh M, Simon M, Canter H, et al. Lipoprotein lipase activity and blood triglyceride levels in fetal and newborn rats. Pediatr Res 1978; 12: 1132-6.
[http://dx.doi.org/doi.org/10.1203/00006450-197812000-00006]
[20]
Camps L, Reina M, Llobera M, Bengtsson-Olivecrona G, Olivecrona T, Vilaró S. Lipoprotein lipase in lungs, spleen, and liver: synthesis and distribution. J Lipid Res 1991; 32(12): 1877-88.
[21]
Linscheer WG, Patterson JF, Moore EW, Clermont RJ, Robins SJ, Chalmers TC. Medium and long chain fat absorption in patients with cirrhosis. J Clin Invest 1966; 45(8): 1317-25.
[http://dx.doi.org/10.1172/JCI105438]
[22]
Bobiński R, Mikulska M. The ins and outs of maternal-fetal fatty acid metabolism. Acta Biochim Pol 2015; 62(3): 499-507.
[http://dx.doi.org/doi.org/10.18388/abp.2015_1067]
[23]
Das UN. Do unsaturated fatty acids function as endogenous antibacterial and antiviral molecules? The Amer J Clin Nutr 2006; 83: 390-1.
[http://dx.doi.org/doi.org/10.1093/ajcn/83.2.390]
[24]
Giron DJ. Inhibition of viral replication in cell cultures treated with prostaglandin E1. Proc Soc Exp Biol Med 1982; 170(1): 25-8.
[http://dx.doi.org/doi.org/10.3181/00379727-170-41390]
[25]
Buckley MS, Goff AD, Knapp WE. Fish oil interaction with warfarin. Ann Pharmacother 2004; 38(1): 50-2.
[http://dx.doi.org/doi.org/10.1345/aph.1D007]

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