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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Selective Targeted Drug Delivery Mechanism via Molecular Imprinted Polymers in Cancer Therapeutics

Author(s): Renuka Suravajhala*, Harshavardhan Reddy Burri and Babita Malik*

Volume 20, Issue 22, 2020

Page: [1993 - 1998] Pages: 6

DOI: 10.2174/1568026620666200622150710

Price: $65


Artificial receptor-like structures such as molecular imprinted polymers (MIPs) are biomimetic molecules are used to replicate target specific antibody-antigen mechanism. In MIPs, selective binding of template molecule can be significantly correlated with lock and key mechanism, which play a major role in the drug delivery mechanism. The MIPs are biocompatible with high efficiency and are considered in several drug delivery and biosensor applications besides continuous and controlled drug release leading to better therapeutics. There is a need to explore the potential synthetic methods to improve MIPs with respect to the imprinting capacity in cancer therapeutics. In this review, we focus on MIPs as drug delivery mechanism in cancer and the challenges related to their synthesis and applications.

Keywords: Molecular imprinting polymers, Biomimetic, Artificial receptor, Drug delivery mechanism, Antibody-antigen, Selective binding, Biocompatible, Cancer.

Graphical Abstract
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