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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Review Article

Berberine Administration in Treatment of Colitis: A Review

Author(s): Milad Ashrafizadeh, Masoud Najafi, Reza Mohammadinejad, Tahereh Farkhondeh and Saeed Samarghandian*

Volume 21 , Issue 13 , 2020

Page: [1385 - 1393] Pages: 9

DOI: 10.2174/1389450121666200621193758

Price: $65


Berberine (Brb) is one of the well-known naturally occurring compounds exclusively found in Berberis vulgaris and other members of this family, such as Berberis aristata, Berberis aroatica, and Berberis aquifolium. This plant-derived natural compound has a variety of therapeutic impacts, including anti-oxidant, anti-inflammatory, anti-diabetic, and anti-tumor. Multiple studies have demonstrated that Brb has great anti-inflammatory activity and is capable of reducing the levels of proinflammatory cytokines, while it enhances the concentrations of anti-inflammatory cytokines, making it suitable for the treatment of inflammatory disorders. Colitis is an inflammatory bowel disease with chronic nature. Several factors are involved in the development of colitis and it appears that inflammation and oxidative stress are the most important ones. With respect to the anti-inflammatory and antioxidant effects of Brb, its administration seems to be beneficial in the treatment of colitis. In the present review, the protective effects of Brb in colitis treatment and its impact on molecular pathways are discussed.

Keywords: Antioxidant, anti-inflammatory, berberine, colitis, inflammatory bowel disease, Berberis aquifolium.

Graphical Abstract
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