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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Review Article

A Glance on the Role of Bacterial Siderophore from the Perspectives of Medical and Biotechnological Approaches

Author(s): Manaf AlMatar*, Osman Albarri*, Essam A. Makky*, Işıl Var and Fatih Köksal

Volume 21 , Issue 13 , 2020

Page: [1326 - 1343] Pages: 18

DOI: 10.2174/1389450121666200621193018

Price: $65


Iron, which is described as the most basic component found in nature, is hard to be assimilated by microorganisms. It has become increasingly complicated to obtain iron from nature as iron (II) in the presence of oxygen oxidized to press (III) oxide and hydroxide, becoming unsolvable at neutral pH. Microorganisms appeared to produce organic molecules known as siderophores in order to overcome this condition. Siderophore's essential function is to connect with iron (II) and make it dissolvable and enable cell absorption. These siderophores, apart from iron particles, have the ability to chelate various other metal particles that have collocated away to focus the use of siderophores on wound care items. There is a severe clash between the host and the bacterial pathogens during infection. By producing siderophores, small ferric iron-binding molecules, microorganisms obtain iron. In response, host immune cells produce lipocalin 2 to prevent bacterial reuptake of siderophores loaded with iron. Some bacteria are thought to produce lipocalin 2-resistant siderophores to counter this risk. The aim of this article is to discuss the recently described roles and applications of bacterial siderophore.

Keywords: Siderophores, microbial virulence, secretion mechanism, interaction with metals, immune response, medical application.

Graphical Abstract
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